Term
|
Definition
| interfere with nucleic acid synthesis |
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Term
|
Definition
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Term
|
Definition
| distrupts DNA structure and funtion |
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Term
|
Definition
| block topoisomerase or microtubule function |
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Term
|
Definition
| affect signaling through steroid receptors |
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Term
|
Definition
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|
Term
| Hematopoeitic Growth factos |
|
Definition
| promote recovery of blood cells after chemo |
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|
Term
| Mechanism of alkylating agents |
|
Definition
| damage DNA by breaks, crosslinks, or mutations (mustards, nitrosoureas, platinum, methylating agents) |
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Term
| Classes of antimetabolites |
|
Definition
| Folate, pyrimidine, and purine analogs, and ribonucleotide reductase (hydroxyurea) |
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|
Term
| Mechanism of folate analogs |
|
Definition
| competitive inhibitor of dihydrofolate reductase (DHFR) |
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|
Term
| Mechanism of pyrimidine analogs |
|
Definition
| suicide inhibitor, kills thymidylate synthase prevents methylation |
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Term
| Classes of antimitotic (natural) agents |
|
Definition
| Microtubule inhibitors and topoisomerase inhibitors |
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|
Term
| mechanism of microtubule inhibitors |
|
Definition
| disrupting MT causes apoptosis; can prevent dissociation or inhibit by binding |
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Term
| mechanism of topoisomerase inhibitors |
|
Definition
| prevent unwinding of DNA or cause double strand breaks |
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Term
|
Definition
| intercalate b/w bases, cause uncoiling, oxygen free radicals, disrupt signal transduction |
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|
Term
| mechanism of L-Asparaginase |
|
Definition
| uses up low levels of asparagines in cancer cells - selective inhibiton of cancer cells |
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|
Term
| classes of hormonal agents |
|
Definition
| glucocorticoids, progestin, antiestrogens, aromatase inhibitors antiandrogens, LHRH agonists |
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|
Term
| Mechanism of glucocorticoids |
|
Definition
| prevent macrophage presentation, stop proliferation and differentiation of leukocytes |
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Term
| classes of immunomodulatory agents |
|
Definition
| cytokines, signaling inhibitors, protein kinase inhibitors, angiogenesis inhibitors, proteosome inhibitors |
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Term
|
Definition
| interferon and interleukins stimulate NK cells to fight, interferon alpha small proteins interfere with protein synthesis |
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|
Term
| mechanism of signaling inhibitors |
|
Definition
| stop surface receptor or other part of signaling pathway from sending signals |
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|
Term
| Use of Imatinib (Gleevac) |
|
Definition
| selective BCR-ABL inhibitor in CML |
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