Term
| Where are the 3 sites of infection for malaria? |
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Definition
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Term
| What malaria medication(s) are used for chemoprophylaxis |
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Definition
| Chloroquine supplemented with primaquine |
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Term
| What malaria medication is used when in an area of chloroquine-resistance? |
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Definition
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Term
| What malaria medication is used for general attacks? |
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Definition
| Chloroquine, quinine/quinidine |
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Term
| Chloroquine is effective against what form of malaria? |
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Definition
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Term
| What is the mechanism of action for Chloroquine? |
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Definition
| Inhibition of heme processing, leading to an intracellular accumulation of heme that is toxic to parasite |
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Term
| What form of Malaria is primaquine effective against? |
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Definition
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Term
| Quinine and Quinidine can disrupt the Na channels, leading to what? |
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Definition
| Cardiac conduction problems |
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Term
| Does mefloquine have a long or short half life? |
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Definition
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Term
| What is the indication for iodoquinol? |
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Definition
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Term
| What is the mechanism of action for Metronidazole |
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Definition
| Formation of reactive oxidation products disrupting membrane and nucleic acid structures |
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Term
| Can you drink alcohol with Metronidazole? |
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Definition
| No, there will be a disulfram-like reactions |
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Term
| What are the 2 drugs used to treat Giardia? |
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Definition
| Metronidazole and Paromomycin |
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Term
| Pentamidine is used to treat what? |
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Definition
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Term
| Pentamide binds to DNA and inhibits DNA replication, similar to what class of drugs? |
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Definition
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Term
| Pentamide inhibits dihydrofolate reductase, similar to what other class? |
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Definition
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Term
| Ivermectin causes paralysis by intensifying GABA-mediated neurotranmission in nematodes. This is similar to what medication? |
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Definition
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Term
| Do corticosteroids increase or decrease the immune system? |
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Definition
| Decrease, there is an increased risk of infections during corticosteroid therapy |
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Term
| Cyclosporine, Tacrolimus, and Sirolimus all have what similar mechanism of action? |
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Definition
| Intere with T cell function |
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Term
| What medication is indicated for inflammation-associated ocular dryness? |
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Definition
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Term
| Does Azathioprine affect T cell or B cell function more? |
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Definition
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Term
| Azathioprine has a drug interaction with what medication? |
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Definition
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Term
| When using azathioprine and allopurinol together, which medication needs to be adjusted? |
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Definition
| Azathioprine needs to be reduced by 1/3 to 1/2 when used with allopurinol |
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Term
| True or False: Mycophenolate inhibits both T and B cell activation |
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Definition
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Term
| Why is it important to keep the patient hydrated when taking cyclophosphamide? |
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Definition
| Cyclophosphamide can cause bladder cystitis that may become hemorrhagic |
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Term
| What medication has a similar mechanism of action to sulfonamides but affects mammalian cells? |
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Definition
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Term
| What medication has an anti-angiogenic action that is teratogenic? |
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Definition
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Term
| What medcation is a recombinant human tumor necrosis factor receptor? |
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Definition
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Term
| What are the 2 drugs that can treat early organ rejection processes? |
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Definition
| Muromonab-CD3 and Anti-thymocyte Globulin |
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Term
| What are the 2 immunoenhancers? |
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Definition
| Cytokines and Bacille Calmette-Guerin |
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Term
| Do cytokines stimulate production of T cells or B cells? |
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Definition
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Term
| What can be used to stimulate RBC if that patient is not on chemo? |
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Definition
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Term
| What is the name of the cytokine that can be used to stimulate RBC production in a patient on chemotherapy? |
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Definition
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Term
| Over-stimulation of WBC production by Sargramostim may cause what? |
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Definition
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Term
| What medication is used internationally as a TB vaccine? |
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Definition
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