Term
| What does NRTI stand for? |
|
Definition
| Nucleoside reverse transcritpase inhibitors |
|
|
Term
| What does NTRTI stand for? |
|
Definition
| Nucleotide reverse transcriptase inhibitors |
|
|
Term
| What does NNRTI stand for? |
|
Definition
| Non-nucleoside reverse transcriptase inhibitor |
|
|
Term
| Are drug holidays recommended for HIV therapy? |
|
Definition
| No, they cause resistance |
|
|
Term
| What are 4 common black box warnings for reverse transcriptase inhibitors? |
|
Definition
| Hematological toxocity, myopathy, lactic acidosis and severe hepatomegaly |
|
|
Term
| Can you use stavudine with zidovudine? |
|
Definition
| No, zidovudine inhibits stavudine |
|
|
Term
| What is an adverse effect of protease inhibitors that is important to remember? |
|
Definition
|
|
Term
| What is the name of the best tolerated NRTI? |
|
Definition
|
|
Term
| Does Zidovudine or Abacavir have a higher incidence of hypersensitivity? |
|
Definition
| Abacavir has a higher incidence of hypersensitivity |
|
|
Term
| What HIV medication causes hyperpigmentation of soles and palms |
|
Definition
|
|
Term
| NNRTIs commonly cause what adverse effect? |
|
Definition
| Rash-can be life threatening |
|
|
Term
| How can you avoid a rash associated with Nevirapine? |
|
Definition
| Avoid rash using low dose therapy initially |
|
|
Term
| How do protease inhibitors work? |
|
Definition
| Inhibits the HIV aspartic protease enzyme, blocking posttranslational processing of essential viral protein products |
|
|
Term
| Do protease inhibitors cause hypo or hyperglycemia? |
|
Definition
|
|
Term
| What is the black box warning for Saquinavir? |
|
Definition
| Bioequivalence-cannot change drug manufacturers |
|
|
Term
| What protease inhibitor is the most potent CYP3A4 inhibitor? |
|
Definition
|
|
Term
| What protease inhibitor contains propylene glycol, likely to cause a disulfram rxn when combined with alcohol? |
|
Definition
|
|
Term
| What protease inhibitor, when combined with ritonavir, can cause intracranial hemorrhage? |
|
Definition
|
|
Term
| What medication is a fusion inhibitor? |
|
Definition
|
|
Term
| How do fusion inhibitors work? |
|
Definition
| Prevent virally induced conformational change in GP41 subunit permitting viral-host cell membrane fusion |
|
|
Term
| Maraviroc combined with thioridazine (antipsychotic) increases risk for what? |
|
Definition
|
|
Term
| What is a big difference between Zidovudine and Didanosine? |
|
Definition
| Didanosine contains phenylalanine |
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