Term
| What's the most common description of a drug's duration of action? |
|
Definition
|
|
Term
|
Definition
| medications that require metabolism to produce their effects |
|
|
Term
| How is a drug changed so that it's more easily excreted from the body? |
|
Definition
| changed from lipid soluble to water soluble so that kidneys can easily excrete it |
|
|
Term
| What is the primary site of drug metabolism? |
|
Definition
|
|
Term
| Which organs receive the highest exposure to absorbed drugs? |
|
Definition
|
|
Term
| What is the simplest factor determining drug distribution? |
|
Definition
| amount of blood flow to body tissues |
|
|
Term
| Which parenteral route of drug administration produces fastest onset of action? |
|
Definition
|
|
Term
| What are the 3 broad categories of routes of drug administration? |
|
Definition
| enteral, topical, parenteral |
|
|
Term
| What is the primary pharmacokinetic process determining the onset of drug action? |
|
Definition
|
|
Term
| What are the four processes of pharmacokinetics? |
|
Definition
| absorption, distribution, metabolism, excretion |
|
|
Term
| What does pharmacokinetics focus on? |
|
Definition
| what the body does to drugs after they are administered |
|
|
Term
| What is the typical length of exclusivity for a new drug? |
|
Definition
|
|
Term
| What are the conditions for which a drug is approved? |
|
Definition
|
|
Term
|
Definition
| application of drugs for the purpose of disease prevention and treatment of suffering |
|
|
Term
| What is stage 4 of the drug approval process? |
|
Definition
| postmarketing surveillance |
|
|
Term
| What was the first comprehensive drug standards publication? |
|
Definition
| U.S. Pharmacopeia in 1820 (USP) |
|
|
Term
| What did the Sherley Amendment to the PFDA do? |
|
Definition
| prohibit sale of drugs w/ false therapeutic claims |
|
|
Term
| What was the first national law passed to regulate drugs and what did it attempt to do? |
|
Definition
| Drug Importation act (1848)- stop entry of unsafe drugs into U.S. |
|
|
Term
| What is the rate/extent to which the active ingredient is absorbed from a drug and becomes available at site of drug action? |
|
Definition
|
|
Term
| What are drugs with more than one active generic ingredient? |
|
Definition
|
|
Term
| What did the National Formulary (NF) focus on originally? |
|
Definition
|
|
Term
| How many phases are there in the drug trial process? |
|
Definition
|
|
Term
| What are phases 1,2,3 of clinical trials of a drug focused on? |
|
Definition
| 1. safety 2. effectiveness 3. potential drug-drug interactions |
|
|
Term
| What was passed in 1992 requiring drug/biologic manufacturers to provide yearly product user fees? |
|
Definition
|
|
Term
| What is the key difference between therapeutic and pharmacologic classification of drugs? |
|
Definition
| therapeutic describes what's being treated, pharmacologic describes how drug acts |
|
|
Term
| What is a prototype drug? |
|
Definition
| the drug to which all others in a class are compared |
|
|
