Term
|
Definition
| GI, bradycardia, bronchospasm |
|
|
Term
|
Definition
|
|
Term
| SNRIs, fluoxetine, sertraline, paroxetine |
|
Definition
|
|
Term
| sertraline and citalopram |
|
Definition
| preferred SSRIs in elderly |
|
|
Term
| low dose SSRI (citalopram 5 mg) |
|
Definition
| reduce fall risk and avoid GI effects |
|
|
Term
| QTc interval prolongation |
|
Definition
| citalopram max dose of 20 mg/day in >60 year old |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| useful for depression, inducing sleep, appetite stimulation |
|
|
Term
| more drowsiness at lower doses (7.5-15mg) |
|
Definition
|
|
Term
|
Definition
| greater effect at higher doses |
|
|
Term
|
Definition
| strong H1 blocker but low anticholinergic |
|
|
Term
| BPSD more acute situations |
|
Definition
| aggressiveness threat to oneself or others; hallucinations with distress |
|
|
Term
|
Definition
| may be useful in more mild cases or sensitive patients |
|
|
Term
|
Definition
|
|
Term
|
Definition
| avoids orthostatic hypotension (25-50mg) |
|
|
Term
|
Definition
| anti-convulsants (carbamazepine) |
|
|
Term
|
Definition
|
|
Term
|
Definition
| may accelerate brain damage in dementia (evidence does not support use in aggressive BPSD) |
|
|
Term
| benzos generally not recommended |
|
Definition
| may be effective for anxiousness/ lack of sleep |
|
|
Term
| paradoxical response can be caused by |
|
Definition
|
|
Term
| benzos of choice for BPSD |
|
Definition
| lorazepam, temazepam and oxazepam |
|
|
Term
| long-acting benzos with active metabolites |
|
Definition
| diazepam, flurazepam, chlorazepate (avoid use in dementia patients) |
|
|
Term
| danger from the hallucinations |
|
Definition
| anti-psychotics are most effective |
|
|
Term
|
Definition
| carry a black box warning in dementia patients; increased risk of death |
|
|
Term
| when should anti-psychotics be used |
|
Definition
| only if patient is at risk of harming his/herself or others |
|
|
Term
|
Definition
| try other meds first, check for appropriate dose, monitor carefully for CNS depression |
|
|
Term
|
Definition
| strongest evidence dementia overall, psychosis and agitation |
|
|
Term
|
Definition
| may worsen psychosis in some patients, ok data for agitation |
|
|
Term
|
Definition
| may help more in areas other than psychosis or agitation, not generally used in dementia patients |
|
|
Term
|
Definition
| lacks evidence , no benefit for agitation/ psychosis in dementia over placebo |
|
|
Term
| 2nd generation (atypicals) |
|
Definition
| have a broader effect on additional neurotransmitters (besides dopamine) |
|
|
Term
| 1st generation (typicals) |
|
Definition
| haloperidol, only good for aggression |
|
|
Term
|
Definition
| not common in eldery (wandering worse, looks like agitation); SE of antiphych |
|
|
Term
|
Definition
| parkinsonism, dystonia, akathisia and tardive dyskinesia |
|
|
