Term
| The MOA and class of Ciprofloxacin (Cipro) is? |
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Definition
| Fluoroquinolone that inhibits bacterial DNA gyrase (bacterialcidal) |
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Term
| What is the drug of choice for Anthrax exposure? |
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Definition
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Term
| What are the therapeutic uses of Cipro? |
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Definition
| infections of respiratory tract, urinary tract, GI tract, bones, joints, skin and soft tissues |
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Term
| Adverse effects of Ciprofloxacin (Cipro) include: |
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Definition
GI- N/V/D,
CNS effects- dizziness, HA, restlessness, confusion
Candida infections of pharynx and vagina may develop, thrush from superinfections
Seizures - rare
Tendon rupture- highest risk in patients older than 60, patients using corticosteroids, and children under 18, pregnancy or breastfeeding
Phototoxicity – not as much as tetracyclines
Cannot take glucocorticoid steroids such as prednisone |
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Term
| There are 2 indications for the use of Cipro in pediatric patients, what are they? |
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Definition
Anthrax Exposure
Complicated UTI |
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Term
| Cipro drug interactions include: |
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Definition
Cationic compounds—Aluminum or magnesium antacids, iron salts, zinc salts, sucralfate, dairy products
Give six hours before Cipro or two hours after
Theophylline—Plasma levels increased by Cipro
Warfarin—Warfarin levels can be elevated (monitor PT)
Tinidazole- increase plasma levels |
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Term
| Levofloxacin(Levaquin) is: |
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Definition
| like Cipro, for respiratory tract infections, UTIs, skin infections |
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Term
| What is Metronidazole (Flagyl) lethal to and what is it's MOA? |
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Definition
| anaerobic organisms only; it causes DNA strand breakage and loss of DNA structure |
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Term
| What is the main drug interaction/patient teaching with Metronidazole (Flagyl)? |
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Definition
| Do not consume alcohol while taking metronidazole or for at least one day after- severe vomiting even mouthwash is even enough to cause problems |
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Term
| Theraputic uses for metronidazole (Flagyl) include: |
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Definition
used for a variety of anaerobic bacterial infections of many systems; also prophylaxis for surgical procedures associated with high risk of anaerobes (colorectal, abdominal, and vaginal surgery); used in combination with tetracycline and bismuth subsalicylate to eradicate H. pylori (peptic ulcers); C. difficile associated colitis
Infections of CNS, abdominal organs, bones and joints, skin and soft tissue, and GU |
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Term
| Metronidazole (Flagyl) has adverse effects that include: |
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Definition
| GI effects are most common N/V/D |
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