Term
| What is the MOA of Gentacicin? |
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Definition
Aminoglycoside
Mechanism of Action: Bind to 30S ribosomal subunit, which inhibits protein synthesis |
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Term
| What are the adverse effects of Gentamicin? |
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Definition
| Ototoxicity, Nephrotoxicity, neuromuscular blockade (treated with Calcium Gluconate IV), and Hypersensitivity, blood dyscrasias, streptomycin associated with neurologic disorders, neomycin causes suprainfections of bowel and intestinal malabsorption; topical neomycin can cause dermatitis |
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Term
| What two antibiotics do you NOT want to mix IV? |
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Definition
| Penicillin and Aminoglycosides |
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Term
| Trough levels of Gentamicin correlates with what? |
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Definition
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Term
| Peak levels of Gentamicin correlates with what? |
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Definition
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Term
| When giving Gentamicin its important to monitor what? |
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Definition
| Renal function, serum levels, adverse effects Peak & trough/ BUN & creatine |
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Term
| Gentamicin peak levels should be drawn when? (Daily / Divided) doses |
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Definition
Daily - don't have to
Divided - 1hr after IM , 30 min after IV
Should be b/n 4-10 mcg/ml |
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Term
| Gentamicin trough levels should be drawn when? (Daily / Divided) doses |
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Definition
Daily - 1 hr prior to next dose
Divided - draw 15-30 min prior next dose
Should be 1-2 mcg/mL |
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Term
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Definition
| More active then gentamicin against Pseudomonas aeruginosa but less against enterococci and Serratia; nebulized tobramycin used for patients with cystic fibrosis |
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Term
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Definition
| Most toxic aminoglycoside; not administered parenterally; used topically for eye, ear, and skin infections; orally to suppress bowel flora prior to surgery; can cause bowel suprainfection (eye drops for infection) |
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