Term
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Definition
| Solid dosage forms intended for insertion into body orifices where they melt to exert local or systemic effects of the drug |
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Term
| Where are suppositories usually used? |
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Definition
| Rectally and vaginally, and occasionally through urethra |
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Term
| Describe the size and shape of rectal suppositories |
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Definition
These suppositories are about 1.5 inches long, are cylindrical, and have a tapered end. They weigh about 2 g.
Infant suppositories are 1/2 size |
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Term
| List some systemic uses of rectal suppositories |
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Definition
sedatives,
tranquilizers,
analgesics |
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Term
| What is the most common use for rectal suppositories? |
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Definition
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Term
| Describe the size and shape of vaginal suppositories |
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Definition
| Globular or oviform and weigh about 5 g |
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Term
| What is the main difference between using a vaginal or rectal suppositories? |
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Definition
| A vaginal suppository may need an applicator |
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Term
| What are vaginal suppositories usually used for? |
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Definition
| To treat infections locally, or for contraception |
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Term
| What is another term for vaginal suppository? |
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Definition
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Term
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Definition
| Vaginal tablets prepared by a compression method, inserted with a plastic inserter to disintegrate |
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Term
| What is another name for a urethral suppository? |
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Definition
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Term
| Describe the size and shape of urethral suppositories |
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Definition
| cylindrical in shape and slender (5 mm in diameter) |
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Term
| List two applications for a urethral suppository |
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Definition
| Local infections, erectile dysfunction |
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Term
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Definition
| Throbroma oil that is polymorphic and melts at body temperature |
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Term
| What are the two forms of cocoa butter/theobroma oil? |
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Definition
Alpha form- metastable, created if ever heated over 60C, much lower melting point
Beta form- stable form |
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Term
| Define water soluble suppository base |
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Definition
polyethylene glycols (PEGs) or glycerinated gelatin
Do not melt, but rather dissolve- so less messy
Slower, allows absorption |
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Term
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Definition
Macromolecular networks that swell but do not dissolve in water
Drug is in matrix, when gel swells in body drug is released |
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Term
| Describe suppository hand rolling |
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Definition
Base and drug are kneaded into a mass in mortal & pestle.
The mass is transferred to a sheet of paper and then rolled by hands to form a cylinder, which is then cut. |
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Term
| Describe suppository compression |
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Definition
| The drug mass is forced into a mold under pressure using a press |
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Term
| Describe suppository fusion |
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Definition
The drug is dispersed in melted suppository base. The mixture is then poured into a suppository mold and cooled.
Only can be used for heat-stable drugs! |
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Term
| Describe suppository packaging |
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Definition
Must be upright
Any melting/cocoa butter ones should be refrigerated |
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Term
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Definition
| Dosage forms designed for application in the ear |
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Term
| List some applications for otic drug delivery |
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Definition
| Treatment of ear infections, inflammation, pain, or for the removal of excessive cerumen (earwax) |
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Term
Define external ear
(list two other terms for it) |
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Definition
Pinna, or auticle
Outside fleshy portion, ear canal, and surface of eardrum |
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Term
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Definition
| The three bones holding the eardrum (not important for pharmacy) |
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Term
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Definition
| The cochlea, semicircular canals, vestibular nerve, eustachian tube |
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Term
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Definition
| Earwax; a combination of the secretions of the sweat and sebaceous glands of the external auditory canal and which forms a sticky semisolid when dry |
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Term
| List some solutions used to remove earwax |
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Definition
| Light mineral oil, vegetable oil, and hydrogen peroxide have been used to soften impacted cerumen |
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