Term
| 5-membered ring containing a sulfur + lactam |
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Definition
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Term
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Definition
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Term
| 5-membered ring containing a double bond + lactam |
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Definition
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Term
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Definition
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Term
| Clavulanic acid, Sulbactam, Tazobactam |
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Definition
| Beta-lactamase inhibitors |
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Term
| Gram positive aerobes and anaerobes except most S. aureus; Gram negative anerobes except Bacteroides fragilis; Neisseria sp. |
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Definition
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Term
| Precursor of semisynthetic penicillins |
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Definition
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Term
| ampicilin and amoxicillin |
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Definition
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Term
| carbenicillin and ticarcillin |
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Definition
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Term
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Definition
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Term
| Aminopenicillins, Carboxypenicillins, Ureidopenicillins |
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Definition
| Extended-spectrum penicillins |
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Term
| activity against Hemophilus and Enterococcus spp |
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Definition
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Term
| Notable for activity against Pseudomonas aeruginosa |
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Definition
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Term
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Definition
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Term
| very often used in community against common skin infections (staph!) |
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Definition
| 1st generation cephalosporins |
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Term
| increased gram negative activity, inactive against pseudomonas sp. |
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Definition
| 2nd generation cephalosporins |
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Term
| popular in pediatric URI due to H. influenzae coverage |
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Definition
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Term
| useful to treat systemic deep infections due to activity against anaerobes |
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Definition
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Term
| Cefaclor, cefuroxime, cefoxitin, and cefotetan |
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Definition
| 2nd generation cephalosporins |
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Term
| broad coverage against gram negative species: major indication in meningitis caused by gram negative aerobes, empiric treatment of many infections |
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Definition
| 3rd generation cephalosporins |
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Term
| an important anti-pseudomonal agent |
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Definition
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Term
| only oral agent in its group, used in the community |
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Definition
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Term
| Ceftazidime, Cefixime, Ceftriaxone, Cefotaxime |
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Definition
| 3rd generation cephalosporins |
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Term
| broad spectrum of activity against gram positive, gram negative, and pseudomonas sp; stable against most beta-lactamases; generally reserved for treatment of nosocomial, multidrug-resistant infections, and febrile neutropenia |
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Definition
| 4th generation cephalosporins |
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Term
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Definition
| 4th generation cephalosporins |
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Term
| broadest spectrum of all clinical antibacterial agents but not MRSA, Chalmydia, Mycoplasma |
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Definition
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Term
| hydrolyzed by dehydropeptidase in brush border of kidney (given in combination with inhibitor (cilastatin) |
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Definition
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Term
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Definition
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Term
| Not an antibacterial but an inhibitor of the dehydropeptidases in the kidney, given to maintain the kinetics of Imipenem |
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Definition
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Term
| Active against gram negative aerobes ONLY (Enterobacteriaceae, Neisseria, H. influenza, some pseudomonas |
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Definition
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Term
| Only clinical example of monobactams; not orally bioavailable, administered IM |
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Definition
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Term
| Alternative to aminoglycosides--- 10-20x more expensive |
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Definition
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Term
| active against gram positive organisms ONLY (MRSA, enterococci, Clostridia spp) |
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Definition
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Term
| most active against gram positive species (large MW); act intracellularly on isoprenyl phosphate lipid carrier) |
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Definition
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Term
| Toxicities include ototoxicity, nephrotoxicity, and Red man syndrome |
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Definition
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