Term
| Cardiac dysfunction, alteration of ion homeostasis, oxidative stress, organellar dysfunction, hypersensitivity myocarditis |
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Definition
| Mechanisms of Cardiotoxicity |
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Term
| antagonism of M2 receptors |
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Definition
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Term
| increased conduction at sinoatrial and atrioventricular nodes |
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Definition
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Term
| increased heart rate; conduction disturbances, supraventricular tachyarrhythmias; exacerbation of angina |
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Definition
| antagonism of m2 receptors |
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Term
| antagonism of m2 receptors; overexcitation of beta-1 adrenergic receptors |
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Definition
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Term
| increased heart activity in very very high levels |
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Definition
| norepinephrine or epinephrine |
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Term
| bombards beta-1 receptor (increased heart activity) |
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Definition
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|
Term
| blocks reuptake of NE, build up of NE, heart rate takes off |
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Definition
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|
Term
| those who abuse are prone to arrhythmias |
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Definition
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Term
| cardiac dysrhythmias, altered coronary blood flow |
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Definition
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Term
| sympathetic activity --> decreased coronary blood flow --> myocardial hypoxia |
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Definition
| necrotic lesions in heart |
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Term
| antimigraine or sympathomimetic drug-induced coronary vasospasms |
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Definition
| altered coronary blood flow |
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|
Term
| inhibition of sodium/potassium ATPases; calcium channel blockade, potassium channel blockade |
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Definition
| Altered myocardial ion homeostasis |
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|
Term
| promotes Na/Ca exchange and increases intracellular calcium--> increases likelihood of arrhythmia |
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Definition
| inhibition of Na/K-ATPase |
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|
Term
| contribute to excitation-contraction coupling |
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Definition
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|
Term
| contribute to pacemaker potentials in SA node |
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Definition
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|
Term
| negative inotropic effect due ot reduced calcium-induced calcium release |
|
Definition
| blockade of calcium channels |
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|
Term
|
Definition
| cardioselective, non-dihydropyridine CCBs |
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|
Term
| cause excessive bradycardia, impaired electrical conduction and depressed contractility |
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Definition
| Verapamil (Isoptin) and Diltiazem (Cardiazem) |
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|
Term
| exacerbate preexistent bradycardia; conduction defects or heart failure |
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Definition
| Verapamil (Isoptin) and Diltiazem (Cardiazem) |
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|
Term
| blockade of the rapid-delayed rectifier current Ikr can lead to prolongation of the cardiac action potential and life-threatening cardiac arrhythmias of the torsades de pointes type |
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Definition
| current mediated by the hERG ion channel |
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Term
| time required to achieve ventricular depolarization, the time to the onset of repolarization and the time required to complete repolarization |
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Definition
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|
Term
| atypical form of ventricular tachycardia, initiated only in the presence of long Q-T interval |
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Definition
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|
Term
| Drug-induced long Q-T syndrome |
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Definition
| Antiarrythmic classes IA, IC, III |
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Term
|
Definition
| Quinidine, Procainamide, Disopyramide |
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Term
|
Definition
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|
Term
|
Definition
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|
Term
| reactive free radicals generated during metabolism of parent molecule; mitochondrial injury with disruption of ATP production |
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Definition
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|
Term
| reduced by flavoenzyme to form a doxorubicin semiquinone radical |
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Definition
|
|
Term
| interfere with calcium handling and generation of ROS --> mitochondrial dysfunction |
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Definition
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|
Term
| interference with beta oxidation, NADH synthesis, electron transport chain, proton gradient, and mitochondrial permeability transition |
|
Definition
| Mitochondrial dysfunction |
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|
Term
| cause mitochondrial dysfunction |
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Definition
| Doxorubicin (Adriamycin), Carvedilol (Coreg) |
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|
Term
| can cause hypersensitivity mycarditis |
|
Definition
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|
Term
| can result in rapidly progressive (and often fatal) heart failure and arrythmia |
|
Definition
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