Term
|
Definition
| nicotinic cholinergic receptor |
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|
Term
| Nicotine: Pharmacologic effects |
|
Definition
| Autonomic ganglia stimulations: PANS-GI (salivation, diarrhea, cramping), SANS-CV (increased HR, BP); adrenal medulla SANS stimulation (catecholamine release); CNS stimulation (confusion, tremors, seisures); skeletal NMJ stimulation then depolarizing blockade |
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Term
|
Definition
| lack of specificity, toxicity, addictive |
|
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Term
|
Definition
| smoking cessation, dementias?, chronic pain? |
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Term
|
Definition
| neuronal nicotinic receptor |
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|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Varenicline: pharmacologic effects |
|
Definition
| 1) provides dopaminergic tone to limit craving and withdrawal in the absence of nicotine. 2) attenuates dopaminergic response to nicotine in CNS |
|
|
Term
| Varenicline: adverse effects |
|
Definition
| headache, nausea, exacerbation of psychiatric illness |
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Term
|
Definition
|
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Term
|
Definition
| Glaucoma, Non-obstructive GI ileus, bladder atony, Sjogren's syndrome (dry mouth, dry eyes) |
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|
Term
| Muscarinic agonist: iris, ciliary, SA, atria, AV, ventricles, veins, arteries, bronchial muscle, bronichial glands, GI motility, GI sphincters, GI secretions, detrusor, sphincter, glands |
|
Definition
| contraction, contraction, decreased rate, decrease contractility, decrease conduction, decrease contractile strength, dilation, dilation, contraction, stimulation, increase, relaxation, stimulation, contraction, relaxation, secretion |
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|
Term
| Muscarinic agonist: adverse effects |
|
Definition
| hypotension (CAD), atrial reentry arrhythmias (decreased ERP), bronchoconstriction, increased acid production (peptic acid disease) |
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Term
|
Definition
| Reversible (Edrophonium, Neostigmine), Irreversible (Organophosphates) |
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|
Term
|
Definition
| transient AChE anionic site binding |
|
|
Term
|
Definition
| carbamylates AChE-->stabilization, reversible |
|
|
Term
| Organophosphates: mechanism |
|
Definition
| phosphorylated AChE is stabile; irreversible |
|
|
Term
|
Definition
| Nicotinic synapse stimulation (myasthenia gravis, reversal of curare); Muscarinic synapse stimulation (GI, GU, glaucoma) |
|
|
Term
| Anti-AChE: adverse effects |
|
Definition
| DUMBBLESS: Diarrhea, urination, miosis, bradycardia, bronchoconstriction, excitation of skeletal muscle/CNS, sweating, salivation, |
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Term
|
Definition
|
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Term
|
Definition
| reacts with phosphoryl group, regenerating active enzyme (must be administered before it ages or it stablilizes enzyme) |
|
|
Term
| Pralidoxime: Pharmacokinetics |
|
Definition
| does not enter CNS because of + charge |
|
|
Term
|
Definition
| organophosphate poisoning |
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