Term
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Definition
inhibit bacterial cell well synthesis by binding to one or more pencillin - binding proteins (PBPs) which in turn inhibits the final transpeptidation step of petidoglycan synthesis in bacterial cell walls. |
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Term
Are carbapenems concentration dependent or time dependent killing.
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Definition
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Term
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Definition
Imipenem/Cilastatin (Primaxin)
Meropenem (Merrem)
Ertapenem (Invanz)
Doripenem (Doribax)
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Term
| Brand name for Imipenem/Cilastatin |
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Definition
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Term
| What is the Cilastatin for in Primaxin |
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
| Describe antibiotic activity of carbapenems |
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Definition
active against most gram (+), garm (-) and anaerboic pathogens.
No atypical coverage
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Term
| Name serious side effects |
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Definition
Seizures in elevated doses and those with renal impairment (mainly imipenem) |
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Term
| Reduce dose of carbapenems in renal impairment? |
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Definition
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Term
| Is it okay to use carbapenems in those with PCN allergies? |
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Definition
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Term
Uricosuric agents (probenecid and allopurinol) can increase levels of carbepenems by interfering with renal excretion.
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Definition
| Statement. Not a question. |
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Term
Carbapenems can decrease serum concentrations of valproic acid leading to a loss of seizure control.
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Definition
| Statement. Not a question. |
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Term
Avoid concomitant use of imipenem with ganciclovir.
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Definition
| Statement. Not a question. |
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