Term
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Definition
| solid dosage forms where the drug is encloses in either a hard shell or soft soluble container |
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Definition
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Definition
- better bioavailability than tablets
- ideal for clinical trials
- elegant (pharmaceutically)
- masks bad taste/odor
- good stability
- flexible formulation |
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Term
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Definition
- unsuitable for very water soluble
- unsuitable for hydroscopic
(absorbs water from environment)
- shells are expensive |
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Term
| gelatin capsule invented in: |
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Definition
| 1834 by dublanc and mothes |
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Term
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Definition
hard gelatin
soft gelatin
starch capsules
hydroxylpropyl methylcellulose capsule |
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Term
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Definition
most common
gelatin formulary is made from hydrolyzed collagen, animal skin, white connective tissue and bones |
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Term
| hydroxylpropyl methylcellulose |
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Definition
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Term
| ways to break down gelatin |
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Definition
A: acidic processing
B: alkali processing
A/B: blend of both |
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Term
| properties of gelatin (1) |
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Definition
1. insoluble in cold water
2. soluble in hot water/gastric fluid
3. tasteles
4. biodegradable
5. stable in dry form
6. susceptible to microbial decomposition
7. gelatin shells can be colored w/FDC approved coloring |
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Term
| capsule/gelatin properties |
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Definition
- soluble containers for solid/liquid dosage formulations
- needs appropriate amount of moisture, needs 13-16% water content
- hygroscopic drugs should be stored with dessicant |
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Term
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Definition
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Term
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Definition
Park-Davis/Warner-Lamber locking mechanism
-apply heat to seal cap |
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Term
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Definition
| Park-Davis/Warner-Lambert locking mechanism, snaps to prevent tampering |
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Term
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Definition
| Park-Davis/Warner-Lambert locking mechanism |
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Term
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Definition
| Park-Davis/Warner-Lambert locking mechanism |
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Term
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Definition
| Elanco/Eli Lilly lockin mechanism, snap to lock |
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Term
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Definition
| Elanco/Eli Lilly locking mechanism |
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Term
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Definition
| R.P. Scherer locking mechanism |
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Term
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Definition
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Term
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Definition
| Eli Lilly locking mechanism |
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Definition
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Definition
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Definition
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Definition
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
| pharmaceutic ingredients in capsules |
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Definition
diluents
lubricants
wetting agents
adsorbents |
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Term
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Definition
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Term
| microcrystalline cellulose |
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Definition
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Term
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Definition
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Definition
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Definition
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Definition
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Term
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Definition
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Term
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Definition
1. empty shell
2. rectification: align empty shell
3. separation: separate cap from body
4. filling: fill with drug
5. joining: place body and cap together
6. discharge: pack and go |
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Term
| what determines capsule size? |
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Definition
- amount/bulk of drug and inert substance
- age of patient, can't give 000 to old or young patient |
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Term
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Definition
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Term
| extended release capsules |
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Definition
| coat the pellets/granules and place in capsule |
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Term
| extemporous compounding (1) |
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Definition
| filling hard gelatin capsules with combo drug, tablet or powder |
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Term
| extemporous compounding (2) |
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Definition
| using hard gelatin capsule as drug source |
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Term
| soft gelatin capsule definition |
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Definition
| one piece hermetically sealed(airtight) dosage form |
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Term
| components of soft gelatin shell |
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Definition
glycerin
polyhydric alchol
plasiticizer
methyl/propyl paraben
paraamino benzoic acid (preservative) |
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Term
| types of drugs inside soft gelatin capsules |
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Definition
liquids
suspensions
pasty materials
dry powder
pelletized materials |
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Term
| process of making soft gelatin capsule |
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Definition
| metering pump dispenses accurate amount of drug into gelatin ribbon, gelatin ribbon is flattened by counter rotating die (die has teeth that are capsule shaped), drop of sphere gelatin capsules |
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Term
| shape of soft gelatin caspules |
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Definition
sphere
oblong
ellipse
tube-shaped |
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Term
| drug-gelatin capsule compatability |
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Definition
| if the drug pH is 2.5-7.5, the pKa of the gelatin capsule must be within this range otherwise hydrolysis of the drug will occur |
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Term
| what liquids can be encapsulated in soft gelatin capsules |
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Definition
1. oil or hydrophobic liquids
2. hydrophilic polymer liquids
(polyethylene glycol PEG)
3. relatively hydrophilic nonvolatile liquids |
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Term
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Definition
| natural materials, free of animal products, less susceptible to change, tamper evident |
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