Term
| This Drug only works on G2 phase of the cell cycle |
|
Definition
|
|
Term
| Which cells are most effected by cancer drugs |
|
Definition
Rapid proliferating cells
Bone marrow
GI tract
Mucosa
Hair Follicles
Gonads |
|
|
Term
| Drugs with Renal Toxicity |
|
Definition
|
|
Term
| Drugs that are Hepatotoxic |
|
Definition
|
|
Term
| Pulmonary Toxic drugs (fibrosis) |
|
Definition
|
|
Term
|
Definition
| Doxorubicin, daunorubicin |
|
|
Term
|
Definition
| Vincristine (peripheral neuropathy) |
|
|
Term
| Acoustic Nerve damage drugs |
|
Definition
|
|
Term
| Major immunosuppressive drugs |
|
Definition
|
|
Term
| Drugs which cause hemorrhagic cystitis |
|
Definition
|
|
Term
| Drug which causes pancreatitis |
|
Definition
|
|
Term
| Drug is a folic acid analog that inhibits dihydrofolate reductase-> decreases protein synthesis |
|
Definition
|
|
Term
| Other uses for methotrexate besides cancer |
|
Definition
| Abortion, extopic pregnancy, RA, psoriasis |
|
|
Term
| Rescue drug for Methotrexate |
|
Definition
|
|
Term
| Pyrimidine analog bioactivated to 5F-dUMP, which covalently complexes folic acid to decrease thymidylate sythase |
|
Definition
|
|
Term
| What antifungal medication is turned into 5-flourouracil |
|
Definition
|
|
Term
| Rescue for 5-flourouracil tx |
|
Definition
|
|
Term
| Purine analog activated by HGPRTase |
|
Definition
|
|
Term
| Increased toxicity by allopurinal |
|
Definition
|
|
Term
| Same mechanism as 6-MP but can be given with allopurinol |
|
Definition
|
|
Term
Free radicles which noncovalently intercalate DNA.
Also inhibits tropoisomerase |
|
Definition
| Doxorubicin and Daunorubicin |
|
|
Term
| Given with Doxorubicin for cardioprotective |
|
Definition
|
|
Term
| Induces free radical formation, complexes with iron and oxygen |
|
Definition
|
|
Term
| Inhibits Topoisomerase II |
|
Definition
|
|
Term
| Covalently x link DNA @ N7. Requires bioactivation by the liver |
|
Definition
| Cyclophosphamide/ifosfamide |
|
|
Term
|
Definition
|
|
Term
| Alkylates DNA with pulmonary fibrosis and hyperpigmentation |
|
Definition
|
|
Term
| Alkaloids that bind to tubulinin M-phase and block polymerization of microtubules to that mitotic spindle cannot form |
|
Definition
|
|
Term
| Can cause paralytic Ilieus and alopecia |
|
Definition
|
|
Term
| Hyperstability polymerized microtubules in M phase so that mitotic spindles cannot brk down |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Inhibits ribonucleotide reductase |
|
Definition
|
|
Term
| SERMS Antagonists in breast and agonists in bone and endometrium |
|
Definition
|
|
Term
| SERM Used in Breast cancer |
|
Definition
|
|
Term
| SERM used in osteoporosis |
|
Definition
|
|
Term
| A monoclonal antibody used against HER-2 (erb-B2) a tyrosine kinase. |
|
Definition
|
|
Term
| Used in CML against the philadelphia chromosome |
|
Definition
|
|
Term
| Monoclonal antibody against CD20 found on most B-cells |
|
Definition
|
|
Term
| This drug is an alkalating agent used in hodgkin lymphoma and may have the side effect of a leukomogenic |
|
Definition
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