Term
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Definition
| inhibits dihydrofolate reductase. can't make thymidine (a pyrimidine). can cause fibrotic lung disease. rescued by leucovorin. |
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Term
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Definition
| pyrimidine analogue. inhibits thymidilate synthase. can't be rescued by leucovorin. |
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Term
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Definition
| purine analogue. inhibits PRPP synthetase. metabolized by xanthine oxidase. |
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Term
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Definition
| purine analogue. Inhibits PRPP synthetase. Can be given with allopurinol |
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Term
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Definition
| pyrimidine analogue. inhibits DNA polymerase. used for AML. |
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Term
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Definition
| hemorhaggic cystitis. transitional cell bladder cancer. |
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Term
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Definition
| end in "-mustine". cross BBB. treat brain tumors. cause neuro probs. |
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Term
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Definition
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Term
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Definition
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Term
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Definition
| generates free radicals. intercalates DNA. cardiotoxic. |
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Term
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Definition
| wilms tumor, ewings sarcoma, rhabdomyosarcoma |
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Term
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Definition
| fragments DNA, pulmonary fibrosis. |
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Term
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Definition
| inhibits ribonucleotide reductase, thereby inhibiting DNA synthesis |
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Term
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Definition
| inhibits topoisomerase II |
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Term
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Definition
| triggers apoptosis. used for lymphomas. |
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Term
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Definition
| estrogen antagonist in breast. agonist in bone. partial agonist in endometrium. |
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Term
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Definition
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Term
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Definition
| vs CD20. used for CLL, NHL |
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Term
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Definition
| inhibits bcr-abl tyrosine kinase |
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Term
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Definition
| blocks microtubule polymerization. neurotoxic. |
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Term
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Definition
| blocks microtubule polymerization. bone marrow suppression. |
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Term
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Definition
| hyperstabilize microtubules |
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