Term
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Definition
| Epithelial cells, breast, prostate, lung colon |
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Term
|
Definition
| Connective tissue, mesenchymal bone, cartilage |
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Term
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Definition
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Term
|
Definition
| Pluripotent cells/testical ovary |
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Term
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Definition
| immature precursor embryonic tissue |
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Term
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Definition
| reduction in immune response, bleeding, anemia |
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Term
| Alkylating Agents target.... |
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Definition
| DNA alkylation, cisplatin, oxaliplatin, carboplatin |
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Term
|
Definition
| not cell cycle specific, Binds DNA through inter and intra strand crosslink |
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Term
|
Definition
alkylating agent
highly lipid soluble CAN CROSS BBB |
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Term
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Definition
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Term
| Anti-metabolites target... and are what phase... |
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Definition
| DNA replication...s phase |
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Term
| Methotrexate is an... that... |
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Definition
Anti-Metabolite
inhibit purine synthesis by blocking dihydrofolate reductase |
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Term
| Methotrexate can be eliminated.... and reversed with.. |
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Definition
| renally, leucovorin folic acid analogue |
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Term
|
Definition
inhibits enzyme theymidylate synthase, inhibits DNA synthesis.
half life elongated by leucovorin |
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Term
|
Definition
inhibits ribonucleotide reductase
blocks ribose to deoxyribose conversion |
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Term
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Definition
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|
Term
| cytosine arabinoside is a |
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Definition
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Term
|
Definition
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Term
| Anthracycline: Doxorubicin |
|
Definition
cell cycle nonspecific
causes various DNA damage
binds to cellular membranes to alter fluidity/ion transport
intercalates into DNA
inhibits top II
creates free radicals |
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Term
|
Definition
mitosis blocking, taxanes, vinca alkaloids.
M phase specific |
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Term
|
Definition
inhibit tubulin polymerization
metabolized by cyp450 |
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Term
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Definition
promotes tubulin polymerization
stabilize microtubules(paclitaxel, docetaxil)
blocks mitosis |
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Term
|
Definition
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Term
|
Definition
top 2
allows first cut, prevents resealing |
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Term
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Definition
must be metabolically activated before it crosslinks DNA
good with radiation to target hypoxic tumors |
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Term
|
Definition
single and double DNA breaks.
pulmonary toxicity is concern
renally eliminated |
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Term
|
Definition
| binds to estrogen receptor |
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Term
|
Definition
maximal kill lower toxicity
effective against heterogenous tumors
slow drug resistance |
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