Term
tretinoin (all-trans retinoic acid)
Mechanism |
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Definition
| binds to retinoid X receptor - RARalpha dimer and replaces a repressor of differentiation |
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Term
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Definition
| retinoic acid syndrome- fever dyspnea, pulmonary infiltrates, pleural effusions |
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Term
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Definition
| acute promyelocytic leukemia |
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Term
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Definition
| generates free radicals by uncoupling mitochondrial oxidative phosphorylation. Causes differentiation of APL cells and inhibits angiogenesis |
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Term
| toxicity of arsenic trioxide |
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Definition
| atrial or ventricular arrythemias |
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Term
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Definition
| exemestane, letrozole, anastrozole. Block conversion of androgens to estrogen. |
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Term
| toxicity of aromatase inhibitors |
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Definition
| musculoskeletal pain,, HA, jt pain, difficulty breathing |
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Term
| target aromatase inhibitors |
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Definition
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Term
| tyrosine kinase inhibitors |
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Definition
| Tamoxifen, imatinib, geftinib, erotinib |
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Term
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Definition
| competitive inhibitor estrogen receptor prevents estradiol from binding |
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Term
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Definition
| estrogen dependent breast cancer |
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Term
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Definition
hot flashes increase in bone or tumore pain if metastasis.
also acts as an agonist of estrogen in some tissues resulting in decrease serum cholesteral and maintenance of bone density |
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Term
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Definition
inhibits constitutively active BCr-ABL tyrosine kinase.
To treat CML
detect abl/bcr by FISH and Rt-pcr |
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Term
| monoclonal antibodies for tyrosine kinase |
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Definition
| trastuzumab, cetuximab, bevacizumab |
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Term
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Definition
MAB that binds Her2 receptor that can be overexpressed on brease cancer cells.
toxicity- heart weakening, CHF- cardiomyapathy and infusion related |
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Term
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Definition
MAB for epidermal growth factor (EGFR or Her1)
USED FOR mestastatic colorectal cancer and non small cell lung, pancreatic, and breast |
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Term
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Definition
infusion reaction- airway obstruction and hypotension
severe acneiform rash/eruption |
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Term
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Definition
inhibits vascular endothelial rgowth factor and inhibits angiogenesis.
treat mestastatic colorectal cancer |
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Term
| bevacizumab treats and toxicity |
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Definition
| metastatic colorectal cancer less infusion reactions than cetuximab. CHF, HTN, proteinuria |
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Term
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Definition
| cd25 target. t-cell mycosis fungoides |
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Term
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Definition
| cd52 b cell CLL, t cell lymphoma |
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Term
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Definition
| CD20- treat B cell lymphoma and CLL |
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Term
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Definition
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Term
| Peripheral sensory neurotoxicity |
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Definition
- cisplatin
- vincristine
- paclitaxel
- ectoposide
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Term
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Definition
- Ifosfamide (confusion)
- Cisplatin (ototoxicity)
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Term
| Mild Bone Marrow Depression |
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Definition
| Vincristine and Bleomycin |
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Term
| Drug interaction for epirubicin |
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Definition
| Cimetidine will cause a increased in serume epirubicin |
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Term
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Definition
| protects frm cardiotoxicity and extravasation of doxorubicin |
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Term
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Definition
Bleomycin forms radicals to cause DNA fragmentation. Does not affect Bone Marrow.
CAUSES pulmonary fibrosis |
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Term
| Topoisomerase dependent DNA strand breakers |
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Definition
doxorubicin, epirubicin
dactinomycin
etoposide |
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Term
| Antimetabolite that inhibits DNA chain elongation |
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Definition
Cytarabine.
its posphorylated to aracytidine triphosphate and binds 3' OH.
Inactivated by cytadine deaminase in liver
bone marrow depression |
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Term
| Cepacitidine drug interaction |
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Definition
| coumarin derived anticoags |
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Term
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Definition
people can not metabolize 6-mercaptopurine. it will accumulate in them and if homo for it die.
intolerant to azathioprine. |
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Term
| 6-mercaptopurine mechanism and toxicity |
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Definition
inhibits purine (guanine) synthesis. incorporated into DNA = strand breaks
toxicity= bone marrow
treat leukemia in kids |
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Term
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Definition
Potentiates Fluorouracil
Inhibits methotrexate and rescues toxicity |
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Term
| Cyclophosphamide toxicity |
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Definition
cardiotoxic, hemorrhagic cystitis- bladder burn caused by acrolein metabolite treat w/ MENSA
and hematuria
Ifosfamide has same but add MESNA to prevent. Also has neurotoxicity- confusion |
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Term
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Definition
alkylating agents
- mechlorathamie-
- cyclophosphamide -bladder burn
- ifosfamide- neuro (confusion)
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Term
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Definition
Cisplatin and carboplatin
(renal treat with hydration, peripheral sensory neuropathy, and ototoxicity) |
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Term
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Definition
| Bisulfan- bone marrow (stem cell) depression |
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Term
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Definition
Carmustine (IV) and Lomustine (oral)
pulmonary fibrosis |
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