Term
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Definition
| absence or inactivation contributes to uncontrolled cell proliferation and cancer |
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Term
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Definition
| presented to a cell by a virus. |
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Term
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Definition
| procedure that allows DNA molecules to be broken into gene-sized fragments that can be reproduced in large amounts and identified. |
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Term
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Definition
| human version of v-ras oncogene. altered form of normal cellular proto-oncogene. |
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Term
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Definition
| single nucleotide base mutation. oftentimes creates an oncogene. |
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Term
| homogeneously staining region (HSR) |
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Definition
| chromosome regions that stain homogeneously rather than having alternate pattern of light and dark bands. |
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Term
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Definition
| common oncogene that arises from amplification in human cancers. |
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Term
| chromosomal translocation |
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Definition
| a piece of one chromosome is broken off and moved to another chromosome. |
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Term
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Definition
| gene containing sequences derived from two different genes spliced together. |
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Term
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Definition
| contains amino acid sequences encoded by both the BCR and ABL genes. |
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Term
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Definition
| short stretch of DNA is lost during replication |
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Term
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Definition
| rearrangement in which DNA segments are moved from one location to another. |
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Term
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Definition
| inversion of TPM3 and NTRK1 gene. |
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Term
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Definition
| stimulates normal cell proliferation (and sometimes abnormally in cancer cells) |
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Term
| platelet-derived growth factor (PDGF) |
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Definition
| protein produced by blood platelets that stimulates the proliferation of connective tissue cells. |
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Term
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Definition
| transmembrane proteins that transmi signals when bound to growth factors into the inside of the cell. |
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Term
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Definition
| in Ras-MAPK pathway that phosphorylates the amino acid tyrosine in target proteins. |
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Term
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Definition
| exhibits activity even in absence of Growth factor (tyrosine kinase and EGF). |
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Term
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Definition
| trigger changes in gene expression that can stimulate proliferation. cytoplasmic proteins-signal transducers and activators of transcription. join together when phosphorylated and mover from the cytoplasm to the nucleus to trigger changes in gene expression. |
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Term
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Definition
| activity of protein regulated by GTP (active) and GDP (inactive). Ras proteins. |
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Term
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Definition
| phosphorylated=active. then it catalyzes phosphorylation of another intracellular protein kinase called MEK. it is just a part in a cascade of phosphorylation reactions |
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Term
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Definition
| phosphorylates the amino acids serine/threonine in targe proteins. coded for by BRAF oncogene. |
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Term
| nonreceptor tyrosine kinase |
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Definition
| intracellular tyrosine kinases that do not possess receptor sites. |
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Term
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Definition
| tyrosine kinase that catalyzes the phosphorylation of cytoplasmic proteins called STATs. |
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Term
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Definition
| proteins that bind to DNA and alter expression of specific genes. |
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