Term
| What is the main indication of bupropion? What makes it different from other drugs used for this purpose? |
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Definition
| Bupropion is an antidepressant. Unlike other antidepressants, it has no serotonergic activity. |
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Term
| What is the mechanism of action of bupropion? |
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Definition
| Norepinephrine and dopamine reuptake inhibitor (no serotonergic action) |
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Term
| How does bupropion compare to SSRIs in the treatment of depression? |
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Definition
| Comparably efficient to SSRIs. Little risk of sexual dysfunction or sedation, modest weight loss with treatment. |
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Term
| Aside from classic depression, what 6 other indications are there for bupropion? |
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Definition
Seasonal affective disorder (SAD)
Smoking cessation
Bipolar disorder
ADHD - 2nd-line after sympathomimetics
Cocaine detoxification (?)
Hypoactive sexual desire |
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Term
| What two goups of psychiatric patients should not be treated with bupropion? |
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Definition
Severe anxiety disorder
Severe panic disorder |
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Term
| Which 4 severe psychiatric symptoms may occur as a result of bupropione treatment? |
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Definition
Hallucinations
Delusions
Catatonia
Delirium |
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Term
| Does bupropion interact with MAOIs? |
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Definition
| Yes. May cause hypertensive crisis. Maintain 14 day "window" between drugs. |
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Term
| Does bupropion interact with anticonvulsants? |
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Definition
Carbamazepine lowers levels of bupropion
Bupropion increases levels of valproate |
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Term
| Buproprion should be avoided in combination with which three other psychiatric drugs? |
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Definition
MAOIs
Lithium - may cause CNS toxicity
Fluoxetine - may cause panic, delirium or seizures |
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Term
| Buproprion may cause which cardiac side-effect when combined with which drug? |
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Definition
| Metoprolol - sinus bradycardia |
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