Term
| Skull and facial bones. Middle age. Gardner syndrome. woven and lamellar bone. Little clinical significance except when they cause obstruction of a sinus cavity, impinge brain or eye, etc |
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Definition
| Osteoma; round ot oval sessile tumors projecting from subperiosteal surface of cortex |
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Term
benign bone tumor of cortex of long bones, less than 2cm in greatest dimension and occur in teens and 20s. Also seen in posterior spine. pain relieved by aspirin
bony mass with radioleucent core |
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Definition
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Term
| larger than 2cm, Vertebrae, pain is dull, achy, and unresponsive to asprin, does not induce marked bony reaction. Tx with radiation can cause malignant transformation |
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Definition
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Term
| Most common malignant bone cancer, occur in men (16:1), Knee (50%), malignant mesenchymal tumor where cancerous cells make bone. RB/p53 genes, occur at site of bone growth, pre-existing disorders |
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Definition
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Term
| big bulky tumors, gritty, gray white, areas of hemorrhage and cystic degeneration. lace like architecture or in broad sheets |
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Definition
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Term
| osteosarcoma with malignant cartilage, 50-60% necrotic with large amounts of vascularization |
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Definition
| chondroblastic osteosarcoma; |
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Term
| Codman triangle, breaks through cortex and lifts the periosteum resulting in reactive periosteal bone formation, 90% pts have metastasis; peak incidence in teenagers, also less frequently in elderly (risk include familial RB) |
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Definition
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Term
| small round cell tumors of bone and soft tissue; Homer-Wright Rosettes, necrosis prominent, diaphysis of tubular long bones, males 10-20 yrs old |
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Definition
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Term
| fever, elevated sedimentation rate, anemia, leukocytosis, desructive lytic tumor with permeative margins and extenstion into soft tissues; onion skin bone deposition |
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Definition
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Term
| Difference between PNET and Ewing Sarcoma |
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Definition
| PNET have neural differentiation; undifferentiated are Ewing Sarcoma; pretty much same tumor with different variants |
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Term
| 11:22 translocation, whites>blacks, between ages of 10-20, youngest age of presentation |
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Definition
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Term
| mixture of mononuclear cells and profusion of multinucleated osteoclast cells; uncommon and benign but locally aggressive |
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Definition
| Osteoclastoma aka Giant Cell Tumor |
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Term
| large red-brown tumors undergoing cystic degeneration. Uniform oval monouclear cells. Necrosis, hemorrhage, hemosiderin depostion and reactive bone formation are common |
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Definition
| Giant cell tumor/ aka osteoclastoma |
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Term
| benign tumor of the bone characterized by multiloculated blood filled cystic spaces presenting as a rapidly growing expansile tumor |
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Definition
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Term
| 17p13 translocation resulting in up-regulation of USP6, a deubiquitizing enzyme |
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Definition
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Term
| "blue bone" cartilage like matrix; Necrosis is uncommon, multinucleated osteoclast like giant cells, plump uniform fibroblast, tan-white septa |
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Definition
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Term
| Pain, swelling, first 2 decades of life, long bones, vertebral bodies, neurologic symptoms, rarely fractures, lytic lesions |
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Definition
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Term
| metasteses to the bones of the hands and feet originate from...? |
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Definition
| lung, kidney or colon (relatively uncommon) |
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Term
| sessile, mushroom shaped ranging from 1-20cm. Cap composed of benign hylain cartilage covered by perichondrium. Attached to by a bony stalk |
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Definition
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Term
| slow growing masses, which can be painful. Usually incidental findings, underlying bones may be bowed and shortened. Stop growing at time of growth plate closure |
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Definition
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Term
| develop only in bones of endochondral origin, occasionally the pelvis, scapula, and ribs and rarely hands and feet |
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Definition
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Term
| Reduced expression of EXT1 or EXT2 |
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Definition
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Term
| osteocartilagenous exostosis |
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Definition
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Term
| endochondromatosis associated with soft tissue hemangiomas |
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Definition
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Term
| syndrome of multiple enchondromas or enchondromatosis |
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Definition
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Term
| Smaller than 3cm and gray-blue and translucent. Well circumscribed nodules of cytologically benign hylaine cartilage, hands and feet, medulla |
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Definition
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Term
| pagets disease of bone is a risk factor for this type of bone cancer |
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Definition
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Term
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Definition
chondrosarcoma, osteogenic sarcoma, ewing sarcoma
all end in SARCOMA!!!! |
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Term
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Definition
| osteochondroma, endochondroma, osteoma, osteoid osteoma, osteoblastoma, giant cell tumor |
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Term
| metaphysis of distal long bones (usually the knee) presents as a pathological fracture |
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Definition
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Term
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Definition
| Ewing Sarcoma, chondrosarcoma |
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Term
| Tumor of the EPIPHYSIS of knee (distal femur, prox tibia) Soap bubble appearance, |
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Definition
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Term
medulla of pelvis and proximal femur; males 30-60
mets to lung |
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Definition
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Term
| what characterizes mets of the bone |
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Definition
| osteolytic tumors of bones (except for mets from prostate), more common than primary bone tumors |
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Term
| Most common cause of osteonecrosis |
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Definition
| fracture, idiopathic, or follow corticosteroid admin |
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Term
| location of most bone infarcts |
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Definition
| medullary cavity ofmetaphysis or diaphysis and subchondral region of epiphysis |
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Term
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Definition
| osteoclast resorb necrotic bone trabeculae; remaining necrotic bone acts as a scaffold for deposition of new bone |
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Term
| infarct of bone causing chronic pain that is initially only noticed with activity and becomes progressively more constant |
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Definition
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Term
| infarct of bone that is generally stable and clinically silent |
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Definition
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Term
| conditions associated with osteonecrosis |
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Definition
| trauma, steroids, infection, the bends, radiation, CT disorder, pregnancy, GAUCHER disease, sickle cell, EtOH abuse, chronic pancreatitis, tumors, epiphyseal disorders |
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Term
| origin of osteomyelitis in children |
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Definition
| usually hematogenous in origin and affecting long bones; usually from trivial injuries of mucosa such as defecation or cheweing, or skin infections |
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Term
| origin of osteomyelitis in adults |
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Definition
| complications of open fractures, surgical procedures nd diabetic infections of the feet |
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Term
| pathogen of osteomyelitis in infants |
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Definition
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Term
| pathogen of osteomyelitis in sickle cell patients |
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Definition
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Term
| pathogen of osteomyelitis in Genitourinary infected patients or drug users |
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Definition
| E. Coli, Pseudomonas, klebsiella |
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Term
| pathogen responsible for 80-90% of osteomyelitis cases (pyogenic) |
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Definition
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Term
location of osteomyelitis seeding in:
a.) neonate
b.) kids
c.) adults |
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Definition
a.) meta, epi, or both
b.) meta
c.) epi, subchondral |
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Term
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Definition
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Term
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Definition
| rupture of periosteum leading to a soft tissue abscess leads to a draining sinus |
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Term
| pathology of osteomyelitis in infants |
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Definition
| infection of epi can spread through the articular surface or along capsular and tendoligamentous insertions in a joint, producing septic or suppurative arthritis which can cause destruction of articular cartilage and permanent disability. |
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Term
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Definition
| develops in jaw and associated with extensive new bone formation |
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Term
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Definition
| small intraosseous abscess frequently involving the cortex and walled off by reactive bone. |
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Term
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Definition
| sleeve of living tissue formed by newly deposited bone around the segment of devitalized infected bone. |
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Term
| complications of chronic osteomyelitis |
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Definition
| pathologic fracture, secondary amyloidosis, endocarditis, sepsis, sqamous cell carcinoma in sinus tract, sarcoma in the infected bone (rare) |
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Term
| sites of skeletal involvement in tuberculous osteomyelitis |
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Definition
| spine (40%), knees and hips |
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Term
| complications of tuberculous osteomyelitis |
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Definition
| tuberculous arthritis, sinus tract formation, psoas abscess, amyloidosis |
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Term
| bones involved in skeletal syphilis |
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Definition
| nose, palate, skull, extremities (especially tibia) |
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Term
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Definition
| massive reactive periosteal bone depo on medial and anterior surface of tibia in syphilis |
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