Term
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Definition
| inhibits DNA transcription by intercalating into the transcription initation complex. This blocks elongation of RNA chain by RNA polymerase. First antibiotic to have anticancer properties |
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Term
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Definition
Alkylates duplex DNA
Both bind to minor groove causing the alkylation of guanosine amino group
does not require reduction |
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Term
| Benzopyrene and aflatoxin |
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Definition
| Non covalent DNA intercalaters and DNA alkyating agents |
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Term
Cisplatin and Mitomycin (red.)
(And other mustard agents) |
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Definition
| Undergo hyrdrolysis and then chemically crosslink with DNA by alkylation |
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Term
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Definition
Pro drugs that alkylates and intercalate
*Requires reduction
From a highly reactive quinone and lose a sugar substituent |
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Term
| Bleomycin, enediyne, leinmycin |
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Definition
cause scission of DNA duplex
Bleo - Molecular machine gun shoots OOH radicals at DNA backbone
Enediyne undergoes bergman as well |
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Term
| Calichaemycin, esperamycin, Dynemycin, enediyne, bleomycin |
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Definition
| cleaves DNA by generating benzene 1,4 diradical species (Bergman) |
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Term
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Definition
| Ethidium bromide, arcidine orange, thalidomide, etoposide, actinomycin |
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Term
| Etoposide (Synthetic derivative) |
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Definition
toxic lignan extracted from plant roots to treat acute lympohcytic leukemia
-From intercalation complex with DNA and topoisomerase 2 ---> preventing religation of DNA strand during replication |
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Term
| Temozoloamide (Nitrosamine) |
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Definition
| anticancer prodrug that is activated to produce a methyldiazonium that covalently attached to duplex DNA via methylation |
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Term
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Definition
| blocks growth of peptide by binding to protein residues; 50th subunit |
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Term
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Definition
| Prevents tRNA bound at A site from transferring to P site; 50th subunit |
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Term
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Definition
Prevents aminoacyl tRNAs from finding the A site
30th subunit |
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Term
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Definition
First tuberculosis
coordinates 16s portion of 30s to prevent binding of N-fromylmethionyl-tRNA |
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Term
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Definition
| N-nitrosamines, alkyl halides, diazoalkanes, temozololmide, aflotoxin, CC1065,benzopyene,Daunomycin |
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Term
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Definition
| Calichaemycin, esperamycin, Dynemycin, enediyne, bleomycin |
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Term
Prodrug antibiotics
Reduction needed: |
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Definition
Cisplatin (Hydrolysis), Fe coordination (Bleomycin)
Mitomycin, daunomycin, dynemecin, calichaemycin, leinmycin |
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Term
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Definition
| phosphate cleavage, nucleoside base hydrolysis |
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