Term
| 3 Types of fibers in connective tissue |
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Definition
| Collagen, Reticular, and Elastic |
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Term
| Mesenchymal Connective Tissue |
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Definition
variety of shapes from stellate to spindle
touch each other but don't connect
empty matrix containing fine reticular (network) fibers and blood vessels |
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Term
| What are the shapes of mesenchymal connective tissue? |
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Definition
| stellate to spindle shaped...dont touch each other |
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Term
| Describe the intercellular matrix of mesenchymal tissue? |
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Definition
| empty-looking matrix containing fine reticular fibers and blood vessels |
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Term
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Definition
cells are fibroblasts which resemble mesenchymal cells
intercellular matrix composed of COARSE collagen bundles IRREGULARLY arranged in a JELLY-LIKE matrix |
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Term
| Describe the Cascade of Connective Tissue |
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Definition
| Mesenchymal Tissue, Fibroblast, Fibrocyte, Connective Tissue Proper, Loose Connective (Areolar, Adipose, and Reticular), Dense Connective Tissue (Regular, Irregular, Elastic) |
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Term
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Definition
| Tissue arising from embryonic mesoderm with a highly vascular matrix that includes various types that support the connecting structures in the body |
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Term
| Areolar Connective Tissue |
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Definition
most common type of connective tissue
consists of fibroblasts, macrophages, mast cells, fat cells, plasma cells, lymphocytes
Intercellular materials consists of collagen fibers intertwined with elastic fibers
matrix is watery and ground substance consists of reticular fibers |
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Term
| What is the primary function of areolar connective tissue? |
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Definition
wraps and cushions organs, holds and carries tissue fluid, inflammation
forms the LAMINO PROPRIA of mucus membranes, packages organs, surrounds capillaries |
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Term
| Loose Reticular Connective Tissue |
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Definition
cells are star shaped
cells SUPPORT areolar tissue
intercellular matrix consist of reticular fibers
Reticular cells lie ON THE RETICULAR NETWORK
Located within lymphoid organs (LYMPH NODES, BONE MARROW and SPLEEN) |
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Term
| What staining method is best for capturing reticular fibers? |
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Definition
SILVER staining will capture only reticular fibers
eosin would pick up collagen fibers too |
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Term
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Definition
consists of adipocytes, forming lobes surrounded by loose connective tissue...and mast cells
little ground substance
intercellular matrix consists of RETICULAR AND COLLAGEN fibers |
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Term
| What are the primary functions of adipose connective tissue? |
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Definition
| Provides reserve food fuel, insulation against heat loss, supports and protects organs |
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Term
| Where is adipose tissue located? |
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Definition
| Under the skin, around the kidneys and eye balls, within the abdomen and breasts |
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Term
| Dense Irregular Connective Collagenous Tissue |
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Definition
cells contain fibroblasts and macrophages
intercellular matrix contain irregular thick COLLAGEN bundles in an IRREGULAR, disordered arrangement
contains ALL THREE FIBERS
Found on dermis of skin, submucosa of digestive tract, fibrous capsules of organs and joints |
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Term
| Dense Regular Collagenous Connective Tissue |
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Definition
cells contain parallel rows of flattened fibroblasts
parallel collagen fibers
o Intercellular material of densely packed, collagen fibers in a regular arrangement
Fibroblast (blast = building) get trapped between the collagen in a linear pattern and is also the major type
Mort tendons and ligaments, and aponeuroses |
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Term
| Dense Regular Elastic Connective Tissue |
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Definition
cells contain parallel rows of flattened fibroblasts
fibroblasts “hidden” when tissue is stained for elastic fibers
Intercellular materials are parallel bundles of this elastic fibers
Will look similar to dense regular collagenous except you can’t see fibroblasts
Maintains shape of a structure while allowing great flexibility |
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Term
| What are the 3 components the extracellular matrix? |
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Definition
| GAGS, Proteoglycans, Glycoproteins |
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Term
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Definition
GAGS – glycosaminoglycans
Linear polymers of disaccharides
Include chondroitin sulfate (a sulfated GAG), dermatan sulfate, heparin sulfate (GAG), and heparin |
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Term
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Definition
Chrondroitin sulfate
Dermatan sulfate
Heparan sulfate
Heparan |
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Term
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Definition
consist of a core protein with one or more GAGs attached to it
larger bc they include GAGS and protein
contain hyaluronic acid which form a hydration shell
Spongy water consistency helps the extracellular |
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Term
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Definition
large polypeptides with carbohydrate side chains that are all involved in cell growth
fibroNECTIN, chondronNECTIN, osteoNECTIN |
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Term
| 3 examples of glycoproteins |
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Definition
| fibroNECTIN, chondronNECTIN, osteoNECTIN |
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Term
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Definition
| connect cells with fibers in the extracellular matrix, allowing cells to move through the matrix |
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Term
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Definition
| cartilage protein in matrix that mediated attachment of chondrocytes to collagen |
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Term
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Definition
is thought to stimulate cell growth…fibroblasts and osteoblasts to replace lost bone
Use modified osteonectins in packing material in oral surgery to help replace lost bone |
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Term
| The most abundant fiber in the extracellular matrix |
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Definition
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Term
| The distance between each collagen fiber in a periodicity |
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Definition
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Term
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Definition
| repeating subunits of collagen, give it its periodicity |
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Term
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Definition
| dermis, bone, dentin, cementum |
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Term
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Definition
| hyaline (found in cartilage) and elastic cartilage |
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Term
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Definition
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Term
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Definition
forms basal lamina
Component of basement membrane
Basement membrane consists of basal lamina and reticular lamina |
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Term
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Definition
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Term
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Definition
1. Begins on the rough ER
• Fibroblasts have expansive rough ER
• Rough ER contains RNA…will stain well
2. Preprocollagen (single chain) is formed first in the rough ER
3. Proline is hydroxylated and hydroxylsine is glycosylated
4. Procollagen (triple helix of 3 chains) molecules are formed in the rough ER and modified in the Golgi
5. Exocytosis of procollagen
6. Cleavage of the telopeptides from procollagen produces tropocollagen (occurs as an extracellular event)
7. Tropocollagen self-assembles to form collagen fibrils |
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Term
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Definition
• Composed of microfibrils and elastin
Microfibrils contain fibrillin
• Fibrilin is the long, elastic component
Elastin contains desmosine and isodesmosine
• Elastic fibers may be stretched up to 150% of their resting length
• Helps distinguish elastic fibers from collagen |
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Term
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Definition
• Type III collagen
• branched
• Thinner than Type 1 Collagen
• Characterized by a higher content of carbohydrate parts than any other collagen type
• Silver stain deposits on reticular fibers, giving a brown to black appearance |
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Term
| Which type of collagen is thinner, 3 or 1? |
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Definition
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Term
| Which type of fibers contain the highest content of carbohydrate parts than any other type of collagen? |
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Definition
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Term
| Microfibrils and elastin compose which type of fiber? |
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Definition
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Term
| Isodesmosine and dsmosine are components of what type of fiber? |
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Definition
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Term
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Definition
| forms a hydration shell around proteoglycans, which helps the extracellular matrix to expand |
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Term
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Definition
| a sheet of pearly-white fibrous tissue that takes the place of a tendon in sheetlike muscles having a wide area of attachment. |
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Term
| Is there elastic fiber in adipose tissue? |
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Definition
| NO, only reticular and collagen |
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Term
| In relation to the reticular network, where do reticular cells lie? |
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Definition
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Term
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Definition
| Blank space between connective tissue cells |
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Term
| Which type of tissue forms the lamina propria of mucous membranes? |
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Definition
| areolar connective tissue |
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Term
| Which type of tissue wraps and cushions organs, its macrophages phagocytize bacteria, and plays an important role in inflammation, and conveys tissue fluid? |
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Definition
| areolar connective tissue |
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Term
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Definition
| soft internal skeleton that support other cell types including white blood cells, mast cells, and macrophages |
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Term
| In which organs are reticular connective tissue usually found? |
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Definition
| Lymph nodes, bone marrow, and spleen |
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Term
| Which type of connective tissue is primarily parallel collagen fibers with a few elastin fibers? |
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Definition
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