Term
|
Definition
1 - NRP, healthy, stabilize
2 - moderatly ill, expect quick recovery
3 - extreme prematurity, critically ill, surgery
4 - complex surgery, ECMO |
|
|
Term
| infants transferred to higher care have - 4 |
|
Definition
| lower ICH, RDS, PDA, infection |
|
|
Term
|
Definition
0 - blue, no pulse, no grimace, limp, no resp
1 - pink/blue, <100bpm, grimace, some activity, slow resp
2 - pink, >100bpm, cries, active, strong cry |
|
|
Term
|
Definition
| 5, 10min <5 - slight increased risk |
|
|
Term
| APGAR score ruling out hypoxia as encephalopathy etiology |
|
Definition
|
|
Term
| when do you need to do 10, 15, 20 min apgar |
|
Definition
|
|
Term
| teratogen valproic acid - 3 |
|
Definition
| ONTD, cardiac/TOF, clefts |
|
|
Term
| highest risk seizure med for anomalies |
|
Definition
|
|
Term
|
Definition
| renal dysplasia, oligo, anuria, arterial hypotension, IUGR, RDS, pulmonary hypoplasia, limb defects, death |
|
|
Term
| lithium teratogen and % - 1 |
|
Definition
|
|
Term
| isotretinoin teratogen % risk and 6 defects |
|
Definition
30-60% - carinofacial, cardiac, neurologic, thymic
20-25% - hydrocephaly, microtia |
|
|
Term
| thalidomide teratogen - 1 |
|
Definition
|
|
Term
| tetracyclines teratogen - 2 |
|
Definition
| enamal hypoplasia, tooth discoloration |
|
|
Term
|
Definition
|
|
Term
|
Definition
| nail hypoplasia, stippled bone epiphyses, hydrocephaly, microcephaly, opth abnormalities, IUGR, developmental delay, TOF |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| closure of ductus, NEC, oligo, pulm HTN, IVH |
|
|
Term
|
Definition
| lethargy, hypotonia, RDS, bone demineralizaton (prolonged) |
|
|
Term
| clavulonic acid teratogen - 1 |
|
Definition
|
|
Term
| live flu vaccine teratogen - 1 |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| nutroprusside teratogen - 1 |
|
Definition
|
|
Term
|
Definition
| SGA, PPROM, SAB, PTD, stillbirth,a bruption, previa, SIDS, childhood asthma, infant colic, childhood obesity |
|
|
Term
|
Definition
| abrupt discontinuation - disress, PTL, demise |
|
|
Term
|
Definition
| 1T - aplasia cutis, coloanal atresia |
|
|
Term
|
Definition
|
|
Term
|
Definition
| persistent pulmomnary HTN |
|
|
Term
| SSRI withdrawal neonatal - 6 |
|
Definition
| >20wk - jittery, RDS, TTN, weak cry, poor tone, NICU admissions |
|
|
Term
|
Definition
| floppy infant, sedation, withdrawal, clefts |
|
|
Term
|
Definition
|
|
Term
| dolutegravir teratogen - 1 |
|
Definition
|
|
Term
|
Definition
| masculinization of female |
|
|
Term
|
Definition
| masculinization of female |
|
|
Term
| finasteride teratogen - 1 |
|
Definition
|
|
Term
| spironolactone teratogen - 1 |
|
Definition
|
|
Term
|
Definition
| SAB, stillbirth, congenital anomalies |
|
|
Term
| hydroxyuria teratogen - 2 |
|
Definition
| stillbirth, congenital anomalies |
|
|
Term
|
Definition
| oligohydraminos, anhydraminos |
|
|
Term
| chemotherapy general teratogen - 2 |
|
Definition
|
|
Term
|
Definition
| SAB, septic Ab, PTD, PROM #1 |
|
|
Term
| #1 risk of IUD in pregnancy |
|
Definition
|
|
Term
|
Definition
| vaginal clear cell, cervical clear cell, GU abnormalities, infertility, RPL, PTL, CIN, vaginal adenosis, breast cancer |
|
|
Term
|
Definition
| genital malformations, MR, miscarrage, IUGR |
|
|
Term
|
Definition
| 1T - SAB, ONTD, CV defect |
|
|
Term
|
Definition
|
|
Term
|
Definition
| MR, IUGR, microcephaly, nail hypoplasia, clefts, heart defects |
|
|
Term
|
Definition
| developmental delays, memory deficits, hydrocephaly, cleft palate, PTD |
|
|
Term
| recommended fish servings by risk of murcery and age |
|
Definition
adult 2-3 servings (4oz) of fish/wk from best choices or 1-2 servings from good choices
start 1-2 servings at 2yo (2oz) |
|
|
Term
|
Definition
| king mackerel, marlin, orangy roughy, shark, swordfish, tile fish from gulf of mexico, bigeye tuna |
|
|
Term
| incidence of T21 in absence of fhx |
|
Definition
|
|
Term
|
Definition
|
|
Term
| incidence of T21 if balanced robertsonian |
|
Definition
|
|
Term
| #1 defect in down syndrome |
|
Definition
|
|
Term
| most common anomalies in down syndrome 5 |
|
Definition
| cardiac defects, NT >6mm in 2T, cystic hygroma, hyperechoic bowel, absent nasal bone |
|
|
Term
|
Definition
|
|
Term
| soft markers in down syndrome - 7 |
|
Definition
| pyelectasis, echogenic bowel, UTD, EIF, duodenal atresia, nuchal fold thickening, limb shortening |
|
|
Term
| major anomalies in T21 - 9 |
|
Definition
| cystic hygroma 22%, hydrops, cardiac 40%, AVSD, diaphragmatic hernia, duodenal atresia 15%, jujenal atresia, ventriculomeagly, IUGR 29% |
|
|
Term
| T18 incidence and survival |
|
Definition
| 1:3000 live births, 10% survival beyond neonatal |
|
|
Term
| most common signs of T18 - 2 |
|
Definition
| IUGR and poly is T18 until proven otherwise |
|
|
Term
| signs of T18 from most to least prevalent - 13 |
|
Definition
| IUGR 87%, overlapping digits 50-70%, polyhydraminos 30-60%, SUA 29%, CBC, rocker feet, echogenic bowel, ventriculomeagly, cardiac enomalies, omphalocele, strawberry head, CNS anomalies, isolated CPC <1% |
|
|
Term
|
Definition
|
|
Term
|
Definition
midline defects - clefts, holopros (75% of all holopros)
polydactyly 77%
CV anomaly 77%
omphalocele
hydrocephalus |
|
|
Term
| what is the most common imprinting disorder |
|
Definition
|
|
Term
| signs of prader-willi / angelman in utero |
|
Definition
| decreased FM in 3T, otherwise normal |
|
|
Term
| cause of prader willi / angelman |
|
Definition
| imprinting, which disease determined by dad, del15q11-13 |
|
|
Term
| smith lemli optiz incidence |
|
Definition
|
|
Term
| most common single gene disorder leading to intellectual disability |
|
Definition
|
|
Term
| smith lemli optiz inheritence |
|
Definition
|
|
Term
| most common congenital anomaly |
|
Definition
|
|
Term
| % cardiac anomalies associated with aneuploidy |
|
Definition
|
|
Term
| risk of recurrence of cardiac anomalies in next pregnancy |
|
Definition
|
|
Term
| highest recurring cardiac anomaly |
|
Definition
| hypoplastic left heart syndrome |
|
|
Term
|
Definition
VSD
pulmonary stenosis
overriding aorta
RV hypertrophy
absence of subpulmonary conus - infundibulum muscle |
|
|
Term
|
Definition
|
|
Term
| recurrence of TOF in nexr pregnancy and in offspring |
|
Definition
| 2.5% sibling, 2.5% offspring |
|
|
Term
| are most cardiac anomalies aneuploity or euploidy |
|
Definition
|
|
Term
|
Definition
| T21, DiGeorge, prune belly, CHARGE, valproate, amantadine, coumadin, DM, T18, T13 |
|
|
Term
| systemic signs associated with TOF - 5 |
|
Definition
| reversed ductal flow, pulmonary atresia, levorotation, poly, hydrops |
|
|
Term
|
Definition
| cefts, cardiac anomalies / TOF, hypocalcemia, skeletal anomalies, thymic aplasia |
|
|
Term
|
Definition
| 2-6mo, earlier if tet spells |
|
|
Term
| what is correlated with TOF prognosis |
|
Definition
| degree of pulmonary atresia |
|
|
Term
|
Definition
|
|
Term
| % CP associated with a perinatal hypoxic event |
|
Definition
|
|
Term
| % CP associated with normal apgars |
|
Definition
|
|
Term
| things associated with CP - 5 |
|
Definition
| IUGR, maternal infection, congenital malformations, multiples, metabolic disorders |
|
|
Term
| definition of hypoxic ischemic encephalopathy |
|
Definition
| disturbed neurologic function within the 5d after birth of a 35wk+ bay |
|
|
Term
|
Definition
|
|
Term
|
Definition
| fetal acidosis, worse with intrapartum fever |
|
|
Term
| long term sequalae of HIE - 2 |
|
Definition
|
|
Term
| short time sequalae of HIE - 6 |
|
Definition
| neuro issues, organ dysfunction, lower LOC, seiures, depressed reflexes, respiratory depression |
|
|
Term
| signs of a neonatal acute intrapartum event - 6 |
|
Definition
APGAR <5 at 5 and 10 min
pH <7
BE <-12
sustained NRFHT
multi organ failure within 72h
MRI brain with HIE changes (non-focal) |
|
|
Term
| signs HIE was caused by acute intrapartum event - 4 |
|
Definition
| NRFHT, event right before delivery, timing of brain injuryr consitent with acute intrapartum event, no other contributing factors |
|
|
Term
| when to get cord gasses - 7 |
|
Definition
| CD for NRFHT, 5m apgar <7, NEFHT, severe IUGR, maternal thyroid disease, intrapartum fever, multiple gestation |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| cause of fetal respiratory alkalosis |
|
Definition
| transient cord compression |
|
|
Term
| cord gasses associated with fetal respiratory acidosis |
|
Definition
|
|
Term
| cord gas pattern most associated with neurologic damage |
|
Definition
|
|
Term
| best cord gas to evaluate risk of neurologic injury |
|
Definition
|
|
Term
| theraputic hypothermia has to be done within ___h of birth and lasts __h |
|
Definition
|
|
Term
| theraputic hypothermia improves - 6 |
|
Definition
| mortality, neurodevelopmental disability, major disability, neuromotor delay, CP, IQ |
|
|
Term
| rate of inifant death and disability in HIE |
|
Definition
| death 15-20%, disability 25% |
|
|
Term
| prognosis of fetal arrhythmia - 5 |
|
Definition
95% resolve
if dont...
20% mortality in 1st year of life
20% chance fetal mortality
67% liklihood of requiring pacing
15% risk of cardiomyopathy |
|
|
Term
| most common cause of fetal arrhythmia - 2 |
|
Definition
| PAC/SVT (220-240) and Afib |
|
|
Term
| causes of fetal heart block andincidence - 3 |
|
Definition
| 55% structual heart disease, 40% lupus antibodies, 5% genetic conduction defect/myocarditis, methothelioma of the AV node |
|
|
Term
| rate of a complete heart block |
|
Definition
|
|
Term
| recurrence of complete heart block |
|
Definition
|
|
Term
| % lupus and sjogerns that have babies with complete heart block |
|
Definition
| 10-60% lupus, 70-95% sjogerns |
|
|
Term
| physiology hayline membrane disease |
|
Definition
| high alveolar surface tension, low surfactant, immature lungs |
|
|
Term
| prognosis hayline membrane disease |
|
Definition
| increased fetal death <32wk |
|
|
Term
| signs hayline membrane disease - 10 |
|
Definition
| tachypnea, nasal flaring, expiratory grunting, cyanosis, retractions, <28wk, atelectsis, pulmonary edema, diffuse ground glass CXR |
|
|
Term
|
Definition
| increased WOB, tachypnea, cyanosis, 34-37wk, CXR diffuse infiltrates and perihilar streaking |
|
|
Term
| benefits of circumcisionj - 5 |
|
Definition
| decreased UTI, penile cancer, HIV, genital ulcers, cervical cancer |
|
|
Term
| contraindications circumcision - 3 |
|
Definition
| prematurity, fhx bleeding, penile abnormalities |
|
|
Term
| physiology dandy walker malformation |
|
Definition
| hypoplasia of cerebellar vermis |
|
|
Term
| signs dandy walker malformation 2 |
|
Definition
|
|
Term
| when does the neural tube close |
|
Definition
|
|
Term
| types of ONTD and incidence |
|
Definition
spina bifidia 50%
anancephaly 45%
encephalocele 5% |
|
|
Term
|
Definition
| absence of all or part of brain, scalp, skin |
|
|
Term
|
Definition
|
|
Term
| causes of anancephaly - 8 |
|
Definition
| multifactorial - obesity, DM, valproic acid, alcohol, carbamazapine, radiation, heat, low folic acid |
|
|
Term
| recurrence rates anancephaly |
|
Definition
| 2%, lowered 60% by 4mg folic acid daily |
|
|
Term
|
Definition
| failure of skull to form with extrusion of brain into membranous sac |
|
|
Term
|
Definition
| failure of fusion of neural tube over 3-4 caudal vertebrae |
|
|
Term
| incidence of spina bifidia |
|
Definition
|
|
Term
| signs of spinabifida and % incidence - 5 |
|
Definition
lemon sign 90%
banana sign (cerebellum)
cisterna magn 95%
arnold chiari herniation
ventriculomeagly 75% |
|
|
Term
| high folic acid goods - 8 |
|
Definition
| beef liver, spinach, black eyed peas, fortified cereals, white rice, asparagus, spaghetti, brussel sprouts |
|
|
Term
| incidence of holoprosencephaly |
|
Definition
| 1:16000 live births, 1:250 abortases |
|
|
Term
| physiology of holoprosencephaly |
|
Definition
| single primitive holoventricle and fused thalamus, failure of diverticulation of proencephalon |
|
|
Term
| types of holoprosencephaly 2 |
|
Definition
alobar - intrahemespheric fissue and falx absent
lobal - most favorable |
|
|
Term
| signs of holoprosencephaly - 2 |
|
Definition
| sickle shaped ventricles, bulb like undivided thalamus |
|
|
Term
| associations with holoprosencephaly - 7 |
|
Definition
| hypotelerosim, cyclopia, narrow nasal bridge, probiscus, clefts, T13, T18 |
|
|
Term
| signs of myelodysplastic kidney - 5 |
|
Definition
| UL, female, poor defined outlike, enlarged, non-communicating cysts of different sizes |
|
|
Term
|
Definition
| enlarged, BL, poorly distended bladder, oligo, defined kidney outline, normal shape kidney, pulmonary hypoplasia, renal failure, hepeatic fibrosis |
|
|
Term
| signs of bladder obstruction - 1 |
|
Definition
| bilateral kidney dilation |
|
|
Term
| signs of UTJ obstruction - 1 |
|
Definition
| area of central dilation where ureter joins kidney |
|
|
Term
| management of sacrococcygeal teratoma |
|
Definition
|
|
Term
| complications sacrococcygeal teratoma - 2 |
|
Definition
| <15% malignant, hemorrhage at birth |
|
|
Term
| cleafts are __% of all congenital anomalies |
|
Definition
|
|
Term
| prevalece of the types of cleft lip/palate combinations |
|
Definition
50% combined - higher in males
50% one or other - palate alone higher in females |
|
|
Term
| % of clefts that are midline |
|
Definition
|
|
Term
|
Definition
| cerebral anomalies, holoprosencephaly, AD (rare), phenytoin, valproic acid, topomax, smoking, alcohol, low folic acid, DiGeorge, treacher collins, amniotic bands, T13, mercury |
|
|
Term
|
Definition
|
|
Term
| congenital cystic adenoid malformation of the lung - physiology |
|
Definition
| harmatoma of the terminal bronchioles |
|
|
Term
| congenital cystic adenoid malformation of the lung - signs - 6 |
|
Definition
| usually UL and in 1 lobe, can cause vena cava compression and hydrops, polyhydraminos, and pulmonary hypoplasia |
|
|
Term
| congenital cystic adenoid malformation of the lung - types - 3 |
|
Definition
1- cysts 1.2cm
2- microcystic
3 - solid lesion |
|
|
Term
| congenital cystic adenoid malformation of the lung - prognosis |
|
Definition
| hydrops is a bad sign, need surgical resection after birth |
|
|
Term
| signs of thenatophoric dysplasia - 6 |
|
Definition
| telephone reciever thigh bones (type 1), bell chest (narrow, short ribs), cloverleaf skull (type 2), flat spine (type 1), redundant folds, under developed lungs |
|
|
Term
| thenatrophoric dysplasia prognosis |
|
Definition
| usually die of respiratory failure in uteruo |
|
|
Term
| thenatrophic dysplasia inheritence |
|
Definition
|
|
Term
| 50% major cause of infant death |
|
Definition
|
|
Term
|
Definition
| indomethacin near delivery, BMTZ, prematurity |
|
|
Term
| Erb-duchenne cause, signs |
|
Definition
|
|
Term
| Klumpkes palsy - cause, signs |
|
Definition
|
|
Term
| prognosis of brachial plexus injuries |
|
Definition
|
|
Term
| % brachial plexus injuries occuring without TOL, in CD |
|
Definition
|
|
Term
| weeks of gestation you would consider neonatal interventions |
|
Definition
20-21+6 - none
22-22+6 - consider NRP and PROM Abx
23-23+6 - consider all meds
24-24+6 - consider CD for fetal inducations
25+ do CD for fetal indications |
|
|
Term
| rate of NICU admission, RDS, and CP in premature vs mature babies |
|
Definition
CP - 0.1 to 0.4%
NICU - 7 to 36%
RDS 1 to 10% |
|
|
