Term
| where is ferrous iron converted to ferric |
|
Definition
mucosal cell
then split from heme |
|
|
Term
| what is ferric iron bound to for immediate transport? |
|
Definition
|
|
Term
| How and Where is iorn stored |
|
Definition
Stored as hemosiderin
Liver and spleen |
|
|
Term
| what happens to transferrin in iron deficiency? overload? |
|
Definition
Deficiency: transferrin up, ferritin down
overload: transferrin down, ferritin up |
|
|
Term
| When should iron be given? |
|
Definition
microcytic anemia
post gastrectomy
evaluation for occult bleeding |
|
|
Term
| oral preparations of iron therapy |
|
Definition
ferrous salts
sulfate, gluconate, fumarate |
|
|
Term
| clinical toxicity of iron |
|
Definition
necrotizing gastroenteritis
metabolic acidosis |
|
|
Term
| Treatment of iron toxicity |
|
Definition
gastric lavage
deferoxamine |
|
|
Term
| where is excess iron deposited? |
|
Definition
| heart, liver, and pancrease |
|
|
Term
| what are the active forms of vit B12? |
|
Definition
| deoxyadenosylcobalamin and methylcobalamin |
|
|
Term
|
Definition
| complexed with IF in distal ileum |
|
|
Term
| how is folic acid absorbed? |
|
Definition
| polyglutamate to monoglutamate then bloodstream |
|
|
Term
| what are the two essential enzymatic reactions that require B12? |
|
Definition
methylmalony-CoA to succinyl-CoA
CH3 H4 to H4 folate |
|
|
Term
| Which reaction can folate reverse? |
|
Definition
|
|
Term
| what does vit b12 and folic acid treat? |
|
Definition
|
|
Term
| Which drug reverses neurological damage? |
|
Definition
|
|
Term
| what is the metabolism of heparin? |
|
Definition
not bound to plasma proteins
does not pass placental barrier
terminated by liver metabolism |
|
|
Term
|
Definition
|
|
Term
|
Definition
| accelerates antithrombin activity which inactivates thrombin and stops production of fibrin |
|
|
Term
| how do you reverse heparin? |
|
Definition
|
|
Term
|
Definition
acts more on Xa
LONGER half-life |
|
|
Term
| This anticoag is given orally |
|
Definition
|
|
Term
| How is coumarin distributed? |
|
Definition
|
|
Term
|
Definition
| prevent vit K dep clot fctrs (2,7,9,10) |
|
|
Term
| this prevents thrombosis post-op |
|
Definition
|
|
Term
| this requires max heparin and warfarin |
|
Definition
| established venous thrombosis |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| which has more side effects, hep or coumarin? |
|
Definition
|
|
Term
| this anti coag inhibits the hepatic metab of mny drugs |
|
Definition
|
|
Term
| These drugs prevent ischemic stroke and cardiac events in patients w/unstable angina |
|
Definition
| clopidogrel and ticlopidine |
|
|
Term
| this is antibody that inhibits glycoprotein IIb/3b |
|
Definition
|
|
Term
| This glycoprotein inhib is a peptide |
|
Definition
|
|
Term
| side effect of platelet inhibs |
|
Definition
|
|
Term
| non pep glycoprotein inhib |
|
Definition
|
|
Term
| this inhibits platelet cAMP phosphodiesterase |
|
Definition
|
|
Term
|
Definition
| activates plasmin, which digests fibrin |
|
|
Term
| how to treat t-PA toxicity |
|
Definition
|
|
Term
|
Definition
anemia of :
renal failure
HIV therapy
chemo |
|
|
Term
| This treats hemophilia B? |
|
Definition
|
|
Term
| this treats hemophilia A? |
|
Definition
|
|
