Term
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Definition
| what is the most common metalloporphyrin and is found in humans? |
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Term
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Definition
| what is the only poryphin that is physiologically important in humans? |
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Term
| pyridoxal phosphate; Hemin |
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Definition
| The synthesis of ALA catalayzed by ALA synthase requires what enzyme? what is the inhibitor? |
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Term
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Definition
| in the reaction where ala is catalayzed by ala synthase what are the substrates? |
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Term
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Definition
| If you have a defiency and you do not form coproporphyrinogen III what will be present in the urine? |
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Term
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Definition
| Lead poisoining is due to an incerease in ALA because of an absence of ? |
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Term
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Definition
| Porphyrias, which are inherited disorders of HEME synthesis are inherited usually by what mode? |
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Term
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Definition
| if this is inhibited you will have red wine or colored urine, red flourescent teeth |
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Term
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Definition
| If you have hydroxymethylbilane synthase deficiency what will accumulate in the urine? |
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Term
| corporphyrinogen III, and the intermediates |
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Definition
| if you have a copropophyrinogen oxidase deficiency what will accumulate in the urine |
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Term
| protoporphyrinogen IX and other intermediates |
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Definition
| If you have a deficiency in protoporphyrinogen oxidase what will accmulate in the urine? |
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Term
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Definition
| If you have a deficiency in uroporphyrinogen decarboxylase what will accumulate in the urine? |
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Term
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Definition
| if you have a deficiency with uroporphyrinogen III synthase |
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Term
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Definition
| The Heme ring is opened up in the ER by? |
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Term
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Definition
| what induces the synthesis of UDP-Glucuronyl Transferase? |
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Term
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Definition
| in this type of jaundice you are making too much bilirubin because of hemolysis (sickle cell disease) |
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Term
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Definition
| in this type of jaundice you would have a problem in the liver, genetic errors, and conjugating enzymes in liver are not mature. There is a problem with the hepatocytes and AST and ALT are increased |
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Term
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Definition
| in this type of jaundice there is a blockage of the bile duct, bile acids accumulate in the plasma and you will have pale color stools and dark urine. Complete obstruction or urobilin is absent (unconjugated bilirubin) an increase in alkaline phosphotase will be seen as well |
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Term
| Tyrosine Hydroxylase; TBH |
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Definition
| what is the rate limiting enzyme that converts tyrosine to DOPA and what is the cofactor that it requires? |
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Term
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Definition
| what is enzyme that allows norepinephrine to be converted to epinephrine |
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Term
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Definition
| Dopamine, norepinephrine, and epinephrine are removed by ? |
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Term
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Definition
| Dopamine is finally converted to? |
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Term
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Definition
| Norepinephrine and epinephrine are finally converted to? |
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Term
| Tryptophan Hydrolase; THB |
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Definition
| Tryptophan is converted to serotonin by what enzyme and what is the cofactor? |
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Term
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Definition
| made from arginine, glycine, and methionine |
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Term
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Definition
| if this is present in the plasma it indicates tissue damage and is used in diagnosing MI |
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Term
| Diazo Reaction and Diazotized sulfanic acid+Biliruin |
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Definition
| what are the methods for producing bilirubin (2)? |
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