Term
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Definition
| stops initiation in prokaryotes, binds to the 30S subunit and distorts its structure, interfering with the initiation of protein synthesis |
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Term
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Definition
| interact with 30S ribosomal subunits, blocking access of the aminoacyl-tRNA to mRNA-ribosome complex |
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Term
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Definition
| an activity of the rRNA of the 50S ribosomal subunit, transfers the amino (or peptide chain ) from the P-site onto the amino acid at the A-site and catalyzes peptide bond formation |
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Term
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Definition
| causes inhibition of furthur elongation of the peptide chain in both prokaryotes and eukaryotes |
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Term
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Definition
| inhibits prokaryotic peptidyltransferase, high levels may also inhibit mitochondrial protein synthesis |
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Term
| clindamycin and erythromycin |
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Definition
| bind irreversibly to a site on the 50S subunit of the bacterial ribosome thus inhibiting translocation |
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Term
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Definition
| inactivates eukaryotic elongation factor (eEF2) preventing translocation |
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Term
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Definition
| binds to minor DNA groove and prevents DNA replication |
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Term
| Quinolones, ciprofloxin, noroblocin |
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Definition
| inihibits DNA gyrase in bacteria and prevents DNA replication |
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Term
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Definition
| inhibits Type II Human Gyrase and prevents DNA replication |
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Term
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Definition
| altered sugar with no 3 prime OH group; prevents elongation and proofreading |
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Term
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Definition
| binds Beta subunits is prokaryotes and prevents transcription |
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