Term
| must be both activated and inactivated for cell cycle to progress |
|
Definition
|
|
Term
| Rb and p53 inhibit ___ to ___ phase |
|
Definition
|
|
Term
|
Definition
| retinoblastoma, osteosarcoma |
|
|
Term
|
Definition
| remain in G0, regenerate from stem cells |
|
|
Term
|
Definition
|
|
Term
|
Definition
| enter G1 --> G0 when stimulated |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| never to go G0, divide rapidly with a short G1 |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| RER synthesizes ___ and ___ |
|
Definition
| proteins and N-linked oligosaccharides |
|
|
Term
|
Definition
| RER in neurons; synthesize neurotransmitters and enzymes |
|
|
Term
|
Definition
| unattached, synthesis of cytosolic and organellar proteins |
|
|
Term
| goblet cells and plasma cells have abundant ___ |
|
Definition
|
|
Term
| Steroid synthesis and detox |
|
Definition
|
|
Term
| liver hepatocytes and adrenal cortex contain abundant ___ |
|
Definition
|
|
Term
| golgi 1) modifies N-oligo on ___ 2) O=oligo on ___ and ___ 3) ___ to proteins for trafficking to lysosomes |
|
Definition
- arg
- ser and the
- mannose-6-phosphate |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| failure of addition of mannose-6-phosphate; coarse facial features, clouded corneas, restricted pint movement, high plasma lysosomal enzymes |
|
|
Term
| catabolism of very long chain FA and AA |
|
Definition
|
|
Term
| plasmalogesn --> neural tissue in what organelle? |
|
Definition
|
|
Term
| proteins to be destroyed are tagged with ___ |
|
Definition
|
|
Term
MT: 1) dimers of ___ and ___
2) ___ GTP molecules
3) ___ retrograde
4) ___ anterograde |
|
Definition
1- alpha and beta
2- 2
3- dynein
4- kynesin |
|
|
Term
|
Definition
| -bendazole, griseofulvin, vincristine, paclitaxel, colchicine |
|
|
Term
|
Definition
| MT polymerizaiton defect; pyogenic infections, partial albinism, peripheral neuropathy |
|
|
Term
|
Definition
|
|
Term
|
Definition
| dyne in arm defect, infertility, bronchiectasis, recurrent sinusitis |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| cilia, flagella, mitotic spindle, axon trafficking, centrioles |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| contents of plasma membrane |
|
Definition
| cholesterol and phospholipids |
|
|
Term
| increased cholesterol --> |
|
Definition
| increased melting temperature and decreased fluidity |
|
|
Term
| increased saturated FA --> |
|
Definition
| increased melting temperature, decreased fluidity |
|
|
Term
| binds K site of Na/K pump |
|
Definition
|
|
Term
| ihibits Na/K pump --> increased Ca |
|
Definition
|
|
Term
|
Definition
| bone, skin, tendon, dentin, facia, cornea, wound repair |
|
|
Term
|
Definition
|
|
Term
|
Definition
| reticulin, blood vessels, uterus, granulation tissue, skin |
|
|
Term
|
Definition
|
|
Term
| collagen synthesis inside the cell |
|
Definition
| pre-procollagen -> hydroxylation with bit C -> glycoslation to form pro collagen -> exocytosis |
|
|
Term
| collagen synthesis outside fibroblasts |
|
Definition
| cleavage of terminal region to form tropocollagen -> covalent lysine-hydroxylysin to make collagen fibrils |
|
|
Term
| collagen type in osteogenesis in imperfecta |
|
Definition
|
|
Term
| symptoms of osteogenesis imperfecta |
|
Definition
| multiple fractures, blue sclerae, hearing loss, dental imperfections |
|
|
Term
| type II osteogenesis imperfecta |
|
Definition
|
|
Term
| defective step in collagen synthesis of osteogenesis imperfecta |
|
Definition
| preprocollagen -> procollagen |
|
|
Term
| symptoms of ehlers danlos |
|
Definition
| hyper extensible skin, bleeding, hyper mobile joints |
|
|
Term
| collagen type in ehlers danlos |
|
Definition
|
|
Term
| defective step of collagen synthesis in ehlers danlos |
|
Definition
| peptide cleavage -> collagen fibrils |
|
|
Term
| collagen defect in alport |
|
Definition
|
|
Term
|
Definition
| nephritis and deafness, ocular disturbances |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| alpha 1 antitrypsin deficiency |
|
Definition
| panacinar emphysema and cirrhosis |
|
|
Term
|
Definition
|
|
