Term
| Primary function of the Cell Membrane |
|
Definition
| compartmentalize the inner contents |
|
|
Term
| Prokaryotes use of Membranes vs Eukaryoes |
|
Definition
| Prokaryotes do not use membranes in cell. Eukaryotes do |
|
|
Term
|
Definition
| Turn very long fattyacids into medium chain fatty acids and then transport them to mitochondria for fatty acid metabolism |
|
|
Term
| Where are Proteins secreted from |
|
Definition
| Endoplasmic Reticulum , and Golgi apparatus |
|
|
Term
| CMC? in respect ot amphipathic molecules |
|
Definition
Critical Micelle Concentration
concentration of lipids which micelles form spontaneously after adding any more lipid |
|
|
Term
| Detergent and Soap lipid aggragation |
|
Definition
|
|
Term
| Interface of a lipid monolayer |
|
Definition
|
|
Term
|
Definition
| unilamellar bilayer vesicles |
|
|
Term
| Phospholipids can form in what types of vesicles |
|
Definition
Unilamellar (Bilayer)
Multilamellar ( Onion)
Micelles |
|
|
Term
| Do phospholipids easily arrange into micelles ? Why |
|
Definition
| No because pairs of acyl chains do not pack well in micelles |
|
|
Term
| Accoring to the Fluid Mosaic Model what is a membrane |
|
Definition
| dynamic structure of lipid and proteins, a fluid matrix. |
|
|
Term
| Accoring to the Fluid Mosaic Model in essecne the membrane is a ? What type of movement is allowed for ALL of its components |
|
Definition
| two dimensional solvent of proteins and lipids substances . Both transational and rotational movement is capapble by proteins and lipids |
|
|
Term
| Lipid Chain order decreases toward what end of a fatty acid chain? Where are the Lipids chain most perpendicular to the memrbane plane ? |
|
Definition
toward the end of the fatty acid chain (middle of memrbane)
Toward the top of the membrane (membrane surface) |
|
|
Term
| What are the classes of memrbane proteins? |
|
Definition
| Integral (intrinsic) and Periphreal (extrinsic) and later added by Engleman Lipid anchored proteins |
|
|
Term
| Who are Singer ,Engelman, and Nicolson? What did they proclaim |
|
Definition
Engleman suggested that membrane more crowded than suggested by Singer and Nicolson. Engleman added Lipid anchored proteins
Nicolson and Singer proposed the Fluid Mosaic Model |
|
|
Term
| How strong is bond between Peripheral membrane proteins and membrane? what interactions cause this bond? how can they be disociated ? |
|
Definition
Loosely associated with membrane,
H-bonds, ionic with polar heads aswell as weak interactions with the hydrophobic layer with amphiphillic alpha-helixes ,
can be disociated with mild detergents or high salt concentrations |
|
|
Term
| Integral Memrbane proteins form what association with memrbane ? Often they are transmembrane but? How can they be removed ? |
|
Definition
| form strong association, dont have to be transmembrane, they can only be removed by denaturing membrane with organic solvents or strong detergents . |
|
|
Term
| why is it hard to research integral membrane proteins? |
|
Definition
| Becuae you have to remove them from membrane by denaturing the membrane with strong detergents or organic solvent s |
|
|
Term
| What is common with the portions Integral protimes that are in contact with the lipid bilayer ? what implications do these common segments of protein have? |
|
Definition
they consist Mostly of alpha helixes and beta sheets.
alpha helixses and beta sheets neutralize the highly polar n-h and c=o of the peptide backbone through H-bond formation |
|
|
Term
| Proteins of a single tranmembrane segment usuallly take form of what structure for that segment? |
|
Definition
|
|
Term
| ask if specific details about glycophorin will be on test |
|
Definition
|
|
Term
| How many times do integral transmembrane proteins usually cross the membrane? |
|
Definition
more than once.
2-12 segments |
|
|
