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| lower the activation energy of the reaction |
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| Things enzymes do to accelerate rates |
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Acid/Base catalysis Covalent Catalysis Metal Ion catalysis Orient reacting groups favorably Ground State destabilization Remote binding of groups Transition state stabilization (Binding) |
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| Active site is often complementary to the |
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| transition state of the reaction |
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| Transition State binding and catalysis lowers |
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| _____ orientation in the active site is important |
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| Thymidylate Synthase inhibitor |
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