Term
| Which spirochete causes syphilis? |
|
Definition
|
|
Term
| Does syphilis present with painful or painless chancre? |
|
Definition
|
|
Term
| What causes the primary lesion in syphilis? |
|
Definition
|
|
Term
| How do we treat syphilis? |
|
Definition
|
|
Term
| Virulence factors of T. pallidum? |
|
Definition
| Outer membrane proteins- promote adherence; hyaluronidase; antiphagocytic coating of fibronectin |
|
|
Term
| How long after primary exposure does primary chancre of syphilis typically appear? |
|
Definition
| 3-4 weeks, can be 10-90 days |
|
|
Term
| Clinical manifestation of secondary syphilis? |
|
Definition
| Generalized mucocutaneous rash |
|
|
Term
| Tertiary syphilis characterized by? |
|
Definition
| Gummas (granulomatous lesions) |
|
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Term
| Name of unethical study in which African-American patients were inoculated w/ syphilis and not treated? |
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Definition
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|
Term
| Screening tests for syphilis? |
|
Definition
| RPR; VDRL (can check CSF), TP-EIA (can check CSF) |
|
|
Term
| What disease state can lead to a false positive RPR screen? |
|
Definition
|
|
Term
| Confirmatory tests for syphilis (following positive screen)? |
|
Definition
|
|
Term
| Which organism causes Lyme disease? |
|
Definition
|
|
Term
| Types of relapsing fever? |
|
Definition
Epidemic = louse-borne (scratching spreads it); B. recurrentis
endemic = tick-borne |
|
|
Term
|
Definition
| Erythema chronicum migrans- bull's eye rash |
|
|
Term
|
Definition
|
|
Term
| How is leptospirosis spread? |
|
Definition
| Animal contact or water/soil contaminated w/ animal urine or feces |
|
|
Term
| Clinical manifestations of leptospirosis? |
|
Definition
| Jaundice, immune complex glomerulonephritis |
|
|
Term
|
Definition
| Icteric leptospirosis: vascular collapse, thrombocytopenia, hemorrhage, hepatic/renal failure |
|
|
Term
| Test of choice for leptospirosis? |
|
Definition
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