Term
| alpha-1 receptors located? what type of receptor? |
|
Definition
on smooth muscle
alpha-adrenergic receptor
sympathetic effects |
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Term
| beta 2 located? receptor type? |
|
Definition
smooth muscle
adrenergic receptor
sympathetic effects |
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Term
| beta 1? located? receptor type? |
|
Definition
heart
beta-adrenergic receptor
sympathetic effects |
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Term
| All parasympathetic effects are mediated by what receptors? |
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Definition
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Term
| Acetylcholine signal termination occurs primarily by? |
|
Definition
| NT degredation by Acetylcholinersterase |
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Term
| Catecholamine signal transduction termination occurs by? |
|
Definition
NT reuptake (both pre and post synaptic receptors)
NT diffusion |
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Term
| Does breakdown play a role in signal termination for acetylcholin? cholinergics? |
|
Definition
Signal termination is dependent on break down for acetylcholine
signal termination is independent of breakdown for the cholinergics. |
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Term
| How are catecholamines broken down |
|
Definition
MAO plays a role in breakdown of virtually all catecholamines
dopamine is also broken down via COMT |
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Term
|
What receptor is also a monovalent cation channel.
What ions move?
|
|
Definition
Nicotinic ACh-Receptor
The receptor interacting with ACh allows Na+ to flow in & K+ to exit the cell. |
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Term
The Gs a-subunit of a G-protein
what receptor?
acts on?
effect on cAMP?
|
|
Definition
|
b1,2,3-adrenergic receptors; D1 dopamine receptor
activates
adenylylcyclase (AC) activity > increased cAMP
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Term
|
The GI a-subunit of a G-protein
what receptor?
acts on?
effect on cAMP?
|
|
Definition
| a2-adrenergic receptor, D2, dopamine receptors; M2 muscarinic ACh receptor decreases AC activity> decreased cAMP |
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|
Term
The Gq a-subunit of a G-protein
what receptor?
acts on? |
|
Definition
|
M1 & M3 muscarinic ACh receptors, a1-adrenergic
activates PLC(a ) >increased IP3+DAG & increased free Ca++
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|
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Term
|
Definition
(1) Increased arterial pressure activates stretch receptors in the aortic arch and carotid sinus.
(2) impulses to the brain stem vasomotor center (VMC).
(3) increases vagal (parasympathetic) outflow and slows the heart.
reduces stimulation of sympathetic stimulation of the heart and blood vessels. |
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Term
| Botulism toxin does what? |
|
Definition
| inhibits the release of ach |
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Term
|
Definition
| inhibit the release of sympathetic neurotransmission |
|
|
Term
|
Black widow spider venom (α-latrotoxin)*
|
|
Definition
| increase release of Acetylcholine |
|
|
Term
|
Definition
| increase the release of sympathetic NT |
|
|
Term
|
Definition
| inhibit reuptake of sympathetic NT |
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