Term
| A pt has experienced malignant hypothermia. Inheritance of malignant hyperthermia is autosomal dominant and may develop during anesthesia. This is an example of: |
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Definition
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| In 1960's Congress gave the FDA authority to demand proof of effectiveness of the products drug companies sell due to the following drug case: |
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Definition
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Term
| The inner ear's vascular supply is primarily from which arterial system? |
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Definition
| Both vertebral branch of subclavian artery and the internal auditory artery |
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Term
| The blood supply to the auditory cortex is supplied by the: |
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Definition
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Term
| The most common drug-drug reaction is: |
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Definition
| complications such as lethargy, confusion, dizziness and/or depression |
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Term
The capillary endothelium and the astrocytic sheath form what is commonly known as the blood-brain barrier
T/F |
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Definition
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Term
| Majority of a drug is excreted by the: |
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Definition
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Term
| The principle site of drug metabolism is the: |
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Definition
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Term
| In most cases, administration of loop diuretics: |
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Definition
| can result in temporary HL that recovers in a short time when administered alone and can have a synergistic effect when used with other ototoxic agents |
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Term
| This refers to the movement of a drug into the systemic circulation: |
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Definition
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Term
| When a new drug is being planned for use in humans, the FDA requires which of the following: |
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Definition
| animal studies precede human studies |
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Term
| Ototoxic medications are particularly damaging to which structure: |
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Definition
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Term
| Ototoxic side effects are most greatly enhanced in pts with |
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Definition
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Term
| Streptomycin is more than likely going to have its damaging effects to the: |
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Definition
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Term
| What is the drug with the greatest cochleotoxic effect? |
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Definition
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Term
| In very high does, salicylates produce: |
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Definition
| HL and tinnitus that are usually reversible |
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Term
| Vancomycin is a glycopeptide that typically causes: |
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Definition
| no hearing or vestibular deficits when used alone |
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Term
Young adults tend to be most susceptible to cisplatin ototoxicity
T/F |
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Definition
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Term
| After reviewing a pts medication list, several drugs have auditory/perceptually-related side effects which could be the primary reason why the pt is in the office. With this info, you should: |
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Definition
1) establish a time line
2) inform the pt of the possible correlations between their medications and symptoms
3) conduct and report all audiometric findings, specifically high frequency HL
4) comment in your report about the symptoms' correlations time line to the referring physician |
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Term
Aminoglycoside ototoxic effects are usually immediate, within 1 hour
T/F |
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Definition
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Term
| In many cases, high freq. PT testing should be coupled with DPOAE testing for monitoring pts for early ototoxicity T/F |
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Definition
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Term
When counseling a pt about their current medication side effects and their audio/vest complaints, EVERY adverse drug reaction on the list should be reviewed in detail
T/F |
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Definition
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Term
| A new pt tells you that several months ago he was hospitalized for an infection and received IV antibiotics, which was a mycin drug. To rule out delayed onset or progressive HL, you should monitor his hearing: |
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Definition
| until one year from the last treatment |
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Term
Elderly are less likely to follow a treatment regimen than children
T/F |
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Definition
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Term
DPOAEs would not be useful in monitoring a pt who has received carboplatin because carboplatin is known to cause damage to the inner hair cells
T/F |
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Definition
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Term
| Studies show only about of people who leave a physicians's office with a prescription take the drug as indicated |
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Definition
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Term
| Vestibular monitoring should be continued throughout treatment and for how long past the final dose? |
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Definition
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Term
Permanent symptoms of vestibular ototoxicity are disequilibrium and oscillopsia
T/F |
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Definition
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Term
| Approx. 1/3 of pts who have received cranial radiation will experience SNHL that is typically: |
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Definition
| late onset, more severe in the high frequencies progressive in nature |
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Term
| A pt asks about a new pill that can protect his hearing from noise exposure. You should encourage this pt to try this new drug T/F |
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Definition
| False - currently no FDA approved otoprotective agents |
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Term
| Describe risk factors that place pts at greater risk for developing ototoxicity |
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Definition
| Very young or old age, renal issues, noise exposure, use of loop diuretics with other ototoxic drugs, use of aminoglycosides with platinum based drugs, use of vancomycin with aminoglycosides, carboplatin with previous cisplatin treatment, pre-existing HL |
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