Term
|
Definition
| Bind CD52, T cell lysis, stem cell transplant prep |
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Term
|
Definition
| Tx: cisplatin nephrotoxicity |
|
|
Term
|
Definition
| VEGF block, anti-angiogenesis |
|
|
Term
|
Definition
| G2, Fe-complex -> free radicals, Sx: pulmonary fibrosis |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Tx: brain tumors (also Lomustine:CCNU) SE: Hepatic veno-occlusive disease |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Alkylate N7 of G, Intrastrand break, Sx: nephro/ototoxic |
|
|
Term
|
Definition
| prodrug purine analog, antimetabolite activated deoxycytidine kinase |
|
|
Term
|
Definition
| methylate at O6 of G, resistance via AGT enzyme |
|
|
Term
| Dactinomycin: Actinomycin-D |
|
Definition
| intercalates DNA (nonspecific), child tumors |
|
|
Term
|
Definition
| glucocorticoid, Sx: osteoporosis, Cushingoid |
|
|
Term
|
Definition
| decr cardiotoxicity of “-rubicin” anthracyclines |
|
|
Term
|
Definition
| Topo2+Intercalates+Radicals, Sx: cardiotoxic, red urine |
|
|
Term
|
Definition
| stabilize Topo2, natural podophyllotoxin |
|
|
Term
|
Definition
| pyrimidine-analog, folic acid complex inhibits dTMP; SE: Hand-Foot disease, increased toxicity w/ Leucovorin |
|
|
Term
|
Definition
| SERD w/ no endometrial cancer like tamoxifen |
|
|
Term
|
Definition
| “nib” so tyrosine kinase inhibitor, HER1 so synergy w/ Cetuximab |
|
|
Term
|
Definition
| pyrimidine antimetabolite, inhibit DNA-poly and RNR |
|
|
Term
|
Definition
| free radical scavenger, inhibits RNR (ribonucleoside reductase) |
|
|
Term
|
Definition
| like cyclophosphamide, Sx: CNS toxic |
|
|
Term
|
Definition
| tyrosine kinase inhibitor for BCR/abl (Philly chromo) & c-kit (GIST) |
|
|
Term
|
Definition
| stabilize Topo1, Sx: Gilberts (gluc-trans) Pts -> jaundice, leukopenia |
|
|
Term
|
Definition
| protein synthesis inhibitor, Sx: pancreatitis, hypersensitivity |
|
|
Term
|
Definition
| reduced folate, given after methotrexate, toxic w/ 5-FU |
|
|
Term
|
Definition
| GnRH agonist -> oversecrete/deplete LH/FSH, decr bone/muscle |
|
|
Term
|
Definition
| purine antimetabolite HGPRT-activated; Avoid allopurinol, TPMT polymorphisms |
|
|
Term
|
Definition
| alkylator, activated by reducing, Sx: hemolytic anemia |
|
|
Term
|
Definition
| block depolymerization of microtubules, M phase; Sx: stocking glove neuropathy |
|
|
Term
|
Definition
| methylate O6-G, Sx: disulfiram-like, AGT resistance |
|
|
Term
|
Definition
| tyrosine kinase inhibitor, Sx: hand-foot syndrome |
|
|
Term
|
Definition
| tyrosine kinase inhibitor, Sx: graying hair, skin discolored |
|
|
Term
|
Definition
| Estrogen agonist on bone / antagonist on breast; Sx: endometrial cancer |
|
|
Term
|
Definition
| interstrand alkylator, Sx: cystitis, Tx: bladder cancer |
|
|
Term
|
Definition
|
|
Term
|
Definition
| block polymerization of microtubules, M-phase; Sx: cumulative neurotoxic, no leukopenia |
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|
