Term
| Name the 4 mechanisms of action of antibiotics |
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Definition
| Cell wall disruption, inhibition of nucleic acid synthesis, inhibition of protein synthesis and anti-metabolite activity. |
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Term
| Define anti-microbial specificity |
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Definition
| Targets only pathogens and not the host |
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Term
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Definition
| Drugs which kill bacteria |
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Term
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Definition
| Drug which stops the development and growth of bacteria allowing the host to kill them. |
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Term
| Define anti-microbial minimum inhibitory concentration |
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Definition
| Lowest anti-microbial concentration that stops growth. |
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Term
| Define anti-microbial time dependent agent |
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Definition
| Anti-microbial agent most effective when present over a long period of time. |
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Term
| Define anti-microbial concentration dependent agent |
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Definition
| Anti-microbial agent most effective when present over a long period of time. |
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Term
| Name factors affecting absorption in pharmacology. |
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Definition
| Lipophilicity, Size of drug molecule, Dissociation in alkali/acid environments, Breakdown in GIT and First Pass Metabolism |
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Term
| In pharmacology, what is bio availability |
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Definition
Measures the effectiveness of oral administration of a drug:
Concentration after oral dose/ concentration after IV dose. |
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Term
| What factors affect drug distribution? |
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Definition
| Binding of drug to plasma proteins and Distribution between body compartments |
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Term
| How is the volume of distribution (V) measured? |
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Definition
| (V)= weight of drug administered/drug in plasma. |
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Term
| In pharamcology what is a steady state? |
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Definition
| Equilibrium point in which the amount of drug leaving the body is equal to the amount entering |
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Term
| In pharmacology what is a loading dose? |
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Definition
| A high first does given in order to reach the steady state more quickly. |
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