Term
| No longer used for influenza A |
|
Definition
Amantadine and Rimantadine.
b/c you hate amanze |
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Term
|
Definition
zanamavir (oral inhalation)
oseltamivir (capsule) also known as tamiflu |
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|
Term
| mechanism of zanamavir and oseltamivir |
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Definition
| neuramindase inhibitor, inhibit removal of salic acid |
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Term
influenza A and B are types of....
rna/ or dna viruses? |
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Definition
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Term
|
Definition
|
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Term
| chain terminator acts on DNA polymerase |
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Definition
| acyclovir, if it terminates a chain, cant CYCL-e |
|
|
Term
| what is acyclovir good for? |
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Definition
|
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Term
|
Definition
|
|
Term
| route of administration for acyclovir, |
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Definition
|
|
Term
| what are prodrugs that get higher levles than acyclovir? |
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Definition
| valacyclovir (valtrex) and famciclovir. both pass through GI and liver to increase levels |
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Term
|
Definition
| ganciclovir/valganciclovir |
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Term
| CMV + HSV and VSV can all use...?? |
|
Definition
foscarnet.
NEt catches everythhing for DNA viruses. |
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Term
| T/F ganciclovir/valganciclovir as well as foscarnet inibit viral DNA poly |
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Definition
T.
gang/val inhhibit triphosphatase of viral DNA polym.
-both are VERY TOXIC. |
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Term
| Reverse transcription inhibitors function |
|
Definition
| block DNA poly from reverse transcription. via action triphosphatase |
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Term
| what is recommended for herpes and zoster |
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Definition
|
|
Term
| what is recommended for CMV |
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Definition
|
|
Term
| 2 types of reverse transcriptase inhibitors |
|
Definition
1. nucleoside RT inhibitors
2. non-nucleoside RT inhibitors |
|
|
Term
| common NRTI and mechanism |
|
Definition
AZT or zidovudine
-Phosphorylated by host enzymes
Tri-P inhibits viral DNA polymerase
Acts as chain terminator
Resistance is common with continued use
Oral or IV, gets into CSF, short half-life
Can diminish perinatal transmission |
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Term
| T/F resistance isnt common in NRTI |
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Definition
| false is common, but very common and rapid in NNRTIS |
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Term
| T/F NNRTI's develop resistance rapidly |
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Definition
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Term
| T/F NNRTI's can prevent perinatal transmission |
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Definition
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Term
|
Definition
| nevirapine, delgvirdine, efavirenz, etravirine. (Never, ever even deliver nucleotides) |
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|
Term
| mechanisms of protease inhibitors |
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Definition
|
|
Term
| T/F protease inhibitors are not as strong as RTI's |
|
Definition
| False, they are more POTENT |
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|
Term
| T/F a lot of drug interactions occur with RTI's b/c of hepatic enzymes |
|
Definition
| FALSE, not RTI's, protease inhibitors. |
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Term
| T/F both NNRTI's and portease inhibitors do NOT develop rapid resistance |
|
Definition
| FALSE, oh hell yes those mofo's do develop resistance, much faster than NRTI's |
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Term
| Function of integrase inhibitors |
|
Definition
| Strand transfer inhibitors |
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|
Term
| Example of integrase inhibitor |
|
Definition
raltegravir
RALtegravir: if your RALley them up, they can't integrate |
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|
Term
| what are the 2 types of entry inhihibtors? |
|
Definition
| fusion and coreceptor antagonist |
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|
Term
| what is a fusion inhibitor |
|
Definition
|
|
Term
| enfuvirtide is an easy drug for patients to take T/F |
|
Definition
sooo false. mad painful, mad expensive.
broke and sad makes me en FUme. |
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Term
|
Definition
coreceptor antagonist
-Binds to CCR5 chemokine receptor on CD4 cells
Patient must have only CCR5-tropic strains of HIV-1 (macrophage-tropic viruses present early in infection). |
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|
Term
| T/F HAART: recommended to use 1 or 2 drugs for standard care |
|
Definition
| FALSEEE 3- or FOURRR. virus on the flooorrr |
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Term
|
Definition
| interferon alfas for hep c, b, HHV8, papillomas |
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