Term
| First Line antimycobaterials |
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Definition
Isoniazid
Rifampacin
Pyrinizinamide
Ethambutol |
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Term
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Definition
| Inhibits mycolic acid synthesis |
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Definition
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Definition
p450 inhibitor
metabolized in liver
various rates of acetylation |
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Term
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Definition
| All tissues- w/ high intracellular concentrations |
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Term
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Definition
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Term
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Definition
Hepatitis
B6 defficiency- peripheral neuropathy, give pyridoxine
Inhibition of Phenytoin metabolism- ataxma |
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Definition
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Definition
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Definition
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Definition
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Definition
| binds to beta subunit of Mb RNA pol --> inhibits transcription |
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Definition
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Definition
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Definition
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Definition
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Definition
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Definition
Reddish/ brown Urine
Hepatitis
Abdominal discomfort
fever
skin eruptions |
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Term
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Definition
| inc elimination of other drugs esp Birth control and HIV proteases- monitor the level |
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Term
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Definition
| doesn't affect CYP450 so use in AIDs patients so don't inc elimination of PI |
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Term
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Definition
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Term
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Definition
| Pyrizinamidase converts it to pyrizinmatoic acid --> unknown MOA |
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Term
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Definition
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Definition
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Term
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Definition
| well distributed in tissues but concentrates in cells |
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Term
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Definition
| active in acidic environments ie lysozomes inside of macropahges |
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Term
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Definition
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Term
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Definition
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Term
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Definition
Hyperuricemia- Pyrazinoic acid inhibits renal secretion of Uric acid --> Gout monitor SGOT (liver enzyme) and uric acid
Heptatitis
Arthralgia, fever, skin rashes |
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Term
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Definition
inhibits arabinosyl tranferase --> inhibits bac wall synthesis
Bacerial static |
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Term
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Definition
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Term
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Definition
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Term
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Definition
| most tissues, including CNS --> used for TB meningitis |
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Term
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Definition
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Term
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Definition
Retrobulbar neuritis- Optic neuritis w/o swelling of optic disc. R/G color blindness- Monthly tests for visual acuity
Peripheral neuritis
HA
Rash |
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Term
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Definition
| occationally used in conjunction with first line tx |
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Term
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Definition
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Term
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Definition
| distributes to tissues, but doens't concentrate in cells |
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Term
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Definition
| Excreted unchanged in urine, no liver metabolism |
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Term
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Definition
Ototoxicity- vistibular and auditory
renal injury
hypersensitivity |
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Term
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Definition
binds 30s subunit of bac ribosome- prevents initiation complex formation.
Inhibits translation |
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Term
| Paraminosalicylic Acid- PSA- MOA |
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Definition
competes with PABA for Mb dihyropterase synthase, interferes with folic acid and thus DNA synthesis
bacteriastatic |
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Term
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Definition
oral
well absorbed
always with food |
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Term
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Definition
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Definition
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Term
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Definition
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Term
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Definition
GI- nausea, abdominal pain, diarrhea, nausea if not given w/ food
Goiter, hypothyroidism
Anemia |
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Term
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Definition
| Inhibits mycolic acid synthesis |
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Term
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Definition
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Term
| Ethionamide- distribution |
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Definition
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Term
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Definition
| Liver metabolizes it to ethionamide sulphoxide |
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Term
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Definition
| ethionamide sulphoxide- kidney excretion |
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Term
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Definition
pyridoxine deficiency
GI- N/D/ pain
hepatotoxicity
allergic reactions |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Definition
widely
concentrates in reticuloendothelil system and is slowly let out, partially accounts for long half life |
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Term
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Definition
| metabolized to several inactive metabolites and excreted in the feces and urine |
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Term
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Definition
Drug accumulation in tissues turns- skin, urine, and feces a red brown color, so people with leprosy don't like it b/c it marks them
GI disturbances |
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Term
| Cycloserine/ kanamycin- MOA |
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Definition
| inhibits cell wall synthesis |
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Term
| Cycloserine/ Kanmycin- use |
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Definition
| rarely used due to poor efficacy and adverse eventes |
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Term
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Definition
Ciprofloxacin
Moxifloxacin
Levofloxacin |
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Term
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Definition
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Term
| Fluroquinolones- disrtibution |
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Definition
| Low intracellular concentration |
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Term
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Definition
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Term
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Definition
| inhibits folate synthesis |
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Term
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Definition
| excreted into bile, reabsorbed, excreted in urine |
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Term
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Definition
well tolerated
Fever, GI, rash, exoliative dermatitis |
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Term
| Dapsone Contratindications |
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Definition
| Don't give to someone with sulfa drug allergies |
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Term
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Definition
Streptomyocin
Paramino Salacylic Acid
Ethionamide
Clofazamine
Cyloserine/ Kanomycin
Fluroquinolones, capreomycin |
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Term
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Definition
Rifampin& Dapsone for 6 mnths
Single lesion- Rifampin, ofloxacin, Minocycline |
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Term
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Definition
| Rifampin, Dapsone, Clofazamine- 12 mos |
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Term
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Definition
Azithromycin
Ethambutol
Rifabutin
Fluroquinolones |
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