Term
| 2 month, four first-line drugs for TB |
|
Definition
| Isoniazid, rifampin, pyrazinamide and ethambutol |
|
|
Term
| what is involved in continuation therapy? |
|
Definition
|
|
Term
| Latent tb treatment regimen |
|
Definition
Isoniazid 9 months
Alternative: rifampin 4 months |
|
|
Term
| drug regimen for drug resistant TB |
|
Definition
all first lines execpt isoniazid. 6-9 mos.
Streptomycin is alternative to ethambutol |
|
|
Term
| How is MDR and XDR TB treated |
|
Definition
initial empiric tx of 7 drugs
4 active drugs taken for 18-24 mos. |
|
|
Term
|
Definition
blocks mycolic acid synthesis
bactericidal for growing bacilli |
|
|
Term
| what is isoniazid most active to? |
|
Definition
|
|
Term
| Forms of resistance to isoniazid? |
|
Definition
lack of KatG protein (conversion of prodrug)
increased InhA- prevent inhibition of cell wall synthesis |
|
|
Term
|
Definition
| peripheral and central nervous system-->pyridoxal phosphate deficiency |
|
|
Term
| This drug is used in prophylaxis of family members |
|
Definition
|
|
Term
|
Definition
inhibts bacterial RNA synthesis
bactericidal |
|
|
Term
|
Definition
|
|
Term
|
Definition
orange bodily fluids (even contact lens)
increases metabolism of several drugs decreasing their effect. |
|
|
Term
| what is rifampin effective against |
|
Definition
|
|
Term
| Pyrazinimide mech of action |
|
Definition
| converted to bactericidal pyraznioic acid by bacteria |
|
|
Term
| when is pyrazinimide bactericidal? |
|
Definition
slightly acidic pH
more active against non-dividing old bacteria |
|
|
Term
| Ethambutol mech of action |
|
Definition
| inhibits arabinosyl transferase, blocking cell wall synthesis |
|
|
Term
|
Definition
well absorbed (oral)
penetrates CSF |
|
|
Term
|
Definition
| green-red color blindness |
|
|
Term
| Second line drugs against Tb |
|
Definition
Fluoroquinolones
Aminoglycosides
Ethionamide
Cycloserine |
|
|
Term
| what is the initial drug regimen for treatment of leprosy? |
|
Definition
| dapsone, rifampin, and clofazimine |
|
|
Term
| These two drugs treat leprosy w/few skin lesions |
|
Definition
|
|
Term
|
Definition
| inhibition of folate synthesis |
|
|
Term
|
Definition
more effective against M. leprae
enterohepatic circulation |
|
|
Term
|
Definition
| hemolysis, methemoglobinemia |
|
|
Term
| What is XDR TB resistant to? |
|
Definition
Isoniazid and Rifampin
Fluoroquinolone
at least one of the 3 other second line drugs |
|
|
