Term
| interactions between this drug and cell membrane components can result in the formation of pores lined by hydrophilic groups present in the drug molecule |
|
Definition
|
|
Term
| which statement about fluconazole is accurate? |
|
Definition
| it inhibits demethylation of lanosterol |
|
|
Term
| tx for candida in immunocompromised pts |
|
Definition
| stop current antibiotics and start amphotericin B |
|
|
Term
| if amphotericin B is administered, the pt should be premedicated w/ |
|
Definition
| diphenhydramine, ibuprofen, prednisone |
|
|
Term
| dose-limiting toxicity of amphotericin B is |
|
Definition
|
|
Term
| candida is a major cause of nosocomial blood-stream infection. the opportunistic fungal infection in this pt could have been prevented by administration of |
|
Definition
| nothing in immunocompromised pts |
|
|
Term
| pt w/ coccidioides immitis, what is DOC |
|
Definition
|
|
Term
| which drug is least likely to be effective in the treatment of esophageal candidiasis if it is used by the oral route |
|
Definition
|
|
Term
| which statement about flucytosine is accurate |
|
Definition
| it is bioactivated by fungal cytosine deaminase |
|
|
Term
| serious cardiac effects have occurred when this drug was taken by pts using the antihistamines astemizole or terfenadine |
|
Definition
|
|
Term
| which drug is most appropriate for oral use in vaginal candidiasis |
|
Definition
|
|
Term
| regarding the clinical use of liposomal formulations of amphotericin B, which statement is accurate |
|
Definition
| they decrease the nephrotoxicity of amphotericin B |
|
|
Term
| which drug used IV for disseminated and mucocutaneous candida infections is an inhibitor of synthesis of fungal cell wall component |
|
Definition
|
|
Term
| amphotericin B clinical use |
|
Definition
| systemic fungal infections, fungal meningitis, UTIs |
|
|
Term
|
Definition
| intestinal or oral candida |
|
|
Term
| clinical use of ketoconozole |
|
Definition
| paracoccidioides brasiliensis, pharyngeal and chronic mucocutaneous candida |
|
|
Term
|
Definition
| systemic histoplasmosis, and other mycosis, opportunistic fungals |
|
|
Term
|
Definition
| aspergillus, local tinea or candidal infections |
|
|
