Term
| 4 Basic kinds of myocology for antifungal |
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Definition
Yeast
2. Endemic Mycoses (Dimorphic Fungi)
3. Invasive Molds (or molds)
4. Non-invasive Molds |
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Term
| What falls into the yeast category? 2 |
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Definition
candida specieces
cryptococcus |
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Term
| what are the most common yeast speices |
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Definition
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Term
| What is a common cause of meningitis |
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Definition
| C. neoformans (type of crypt |
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Term
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Definition
| septated hypahe Nonseptate hyphae |
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Term
| Most common type of invasive mold |
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Definition
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Term
| is aspergillus sepated or nont septated |
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Definition
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Term
septated means branching 90 deg
T/F |
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Definition
| false, septated is 45, nonseptated is 90 |
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Term
| What do polyenes do. and give ex |
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Definition
| bind to ergosterol. creates pores in mem cause leaking of poatssium and other moelcules |
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Term
| What does amophtericin B cover |
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Definition
| fungicidal and most year/ molds |
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Term
| What are the 2 types of amphotericin B |
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Definition
| conventional and lipid formulation |
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Term
| Why is the benefit of lipid formulations |
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Definition
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Term
| what is strangeabout what amphotericin can treat? |
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Definition
| doesnt gets int CSF but can treat funcal meningitis |
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Term
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Definition
| super long, beta , dont know where that shit goes |
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Term
| T/F Conentional Amph B is adjusted for renal toxciity |
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Definition
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Term
| T/F lipid formulation of ampho bea is 5-10x higher than conventional |
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Definition
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Term
| Amphotericin B is drug of choice for |
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Definition
1. serious candid infection
-crypto meningitis
meningits from histo or blasto
standar therapy for mucormycosis |
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Term
| Azoles are standard therapry for mucormycosis? T/f |
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Definition
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Term
| Fluclosine is good for cyptocoocal meningits including menin from histo or blasto |
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Definition
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Term
| Misceallaneous antifungals |
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Definition
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Term
| T/F flucytosine canbe used alone |
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Definition
| F. cannot needs tobe used in combo or resistance |
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Term
| What is flucytosine used in combo with |
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Definition
| amph B for cryptomenint for first 2 weeks then switches to fluconzole. (THATS IT!! ONLY FUCNTION |
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Term
| Whhen is the only time flucytosine is used |
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Definition
| in combo w/ AMBO for cyrpotoccal menngitis (first 2 weeks only) |
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Term
| how long do you use flucytoisne for |
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Definition
| first 2 weeks of crypto menin w/ ammpho B |
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Term
Azoles :imidazoles and traizoles
function |
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Definition
| inhibit syntehsis of ergostero |
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Term
| what is the different between azoles and ampho B |
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Definition
| azoels inhibit syn, ampho binds and make holes. |
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Term
| what is newer version of azoles |
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Definition
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Term
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Definition
| candida and cyrpotococcus |
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Term
| Fluconazole covers candid krusei and candida glabrata (T/F |
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Definition
| F NO COVERAGE AGAINST THEM. dont forget mofo |
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Term
| What replaces ampho _ flucylocine w/ cyrpt menin? |
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Definition
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Term
| what is special about itraconzole |
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Definition
Asperigillus coverage first azoel.
I-tra-aperagus. (itraconazole asperigillus |
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Term
| What is drug of choice for aspergillus |
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Definition
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Term
| what is a unique side effect about voricnazole |
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Definition
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Term
| What is the impt azole to treat mucor |
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Definition
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Term
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Definition
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Term
| mechansims of caspofungin |
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Definition
| inhibist cell wall synthesis, different then cell membrane synthesis, exterior to it. |
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Term
| New echinocandins are approved for |
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Definition
| Micafungin, andiulafungin |
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