Term
|
Definition
|
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Term
|
Definition
| Binds egosterol to disrupt fungal membrane |
|
|
Term
| Ampho-B role of deoxycholate |
|
Definition
| Must be compexed to deoxycholate for solubitliy |
|
|
Term
|
Definition
IV
Intrathecally
bladder wash |
|
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Term
|
Definition
| Systemic fungal infections |
|
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Term
|
Definition
Attacks renal cells and RBC's
K, Mg, HCO3 wasting- hydrate and monitor
Infusion related- fever, chills, riggor, hypotenstion, myalgia, arthralgia, HA- premedicate with APAP, NSAIDS and others
Thrombophlebitis- prevent with heparin
Amenia- suppresses EPO |
|
|
Term
|
Definition
Better formulations dec nephrotoxicity and allow larger doses BUT
don't do anything for rigor and infusion rxn
much more expensive |
|
|
Term
|
Definition
| binds to ergosterol and disrupts membrane |
|
|
Term
|
Definition
| oral, vaginal, skin candidiasis |
|
|
Term
|
Definition
topical
swish and swallow
not orally absorbed |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
Flucytosine --> 5- Flurouridylic acid via cytosine deaminase--> inhibits translation
5- Flurodeoxyuridylic acid --> inhibits thymylate synthase --> inhibits DNA synthesis |
|
|
Term
|
Definition
used with Amphoteracin B for cryptococcal meningitis
Never use alone, resistance develops to quickly |
|
|
Term
| Flucytosinse- administration |
|
Definition
|
|
Term
| Flucytosine- distribution |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
Bone marrow suppression
GI- N/V/D
Livertoxicity- reversible |
|
|
Term
|
Definition
Caspofugin
Micafugin
Andidafugin |
|
|
Term
|
Definition
| inhibit beta 1,3 glucan synthesis- inhibit cell wall production |
|
|
Term
|
Definition
|
|
Term
|
Definition
| systemic Candida or Apergillus infections |
|
|
Term
| Echinocandins - drug interactions |
|
Definition
| Cyclosporine inc blood levels of Caspofugin |
|
|
Term
| Echinocandins- Protein binding |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Echinocandins- CNS penetration |
|
Definition
|
|
Term
|
Definition
Histamine related rxns- warmth, swelling, rash
Headache
Hepatotoxicity |
|
|
Term
|
Definition
Inhibits mitotic spindle formation
binds to human keratin which prevents invasion of fungus.
Infected cells slough off eventually non-infected keratinocytes at the basal layer eventually replace |
|
|
Term
|
Definition
| Oral- best with fatty foods |
|
|
Term
|
Definition
| Fungal infections of: Hair, skin, and nails |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Headache, Hepatotoxicity, Neuro/leuckopenia, basophilia, photosensitivity, GI, Rash |
|
|
Term
| Griseofluvin- Effect on enzymes |
|
Definition
|
|
Term
| Griseofluvin- Drug interactions |
|
Definition
| Inc metabolism of Warfarin and Oral contraceptives |
|
|
Term
|
Definition
| binds squalene epoxidase --> inhibits ergosterol synthesis |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Mycoses of nails, drug accumulates in the nail beds |
|
|
Term
|
Definition
| 400 hrs b/c accumulates in hair, skin, and fat and slowly releases |
|
|
Term
| Terbinafine- Protein binding |
|
Definition
|
|
Term
|
Definition
Well tolerated
Uncommon AE- GI, hepatatoxicity, stevents Johnson syndrome |
|
|
Term
| Terbinafine- drug interactions |
|
Definition
| Cimetidine- increases levels of Terbinafine |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Ketoconazole, Clotrimazole, Miconazole, Econazole, Butoconazole, Oxiconazole |
|
|
Term
|
Definition
| All topical except Ketoconazole which is for systemic |
|
|
Term
|
Definition
| Terconazole, Itraconazole, Fluconazole, Voriconazole, Poscanzole |
|
|
Term
|
Definition
| All systemic except for Terconazole which is topical |
|
|
Term
|
Definition
| bind 14 alpha demethylase --> inhibit ergosterol synthesis |
|
|
Term
|
Definition
|
|
Term
|
Definition
Mostly, topical, but some systemic
Superficial infections- ringworm, candidiasis, tinea versicolor/ nigra, fungal keratitis
NOT FOR NAIL/HAIR- THOSE REQ SYSTEMIC |
|
|
Term
|
Definition
Oral.
Require acidic environment for absorption. Drugs that inhibit acidity in the stomach dec absorption (Histamine2 and PPI) |
|
|
Term
|
Definition
Inhibitor
Inc levels of other drugs |
|
|
Term
| Ketoconazole- AE- hormonal effects |
|
Definition
| Hormonal due to CYP450 inhib- dec libido, gynecomastia, menstral irregularities. Blocks androgen, cortisol, aldosterone syntehsis and adronergic receptor antagonist |
|
|
Term
| Ketoconazole- AE- non hormonal |
|
Definition
GI- dose dependent
rash
hepatotoxicity |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| GI absorption- empty stomach and acid |
|
|
Term
|
Definition
|
|
Term
| Itraconazole- protein binding |
|
Definition
| protein binding parent and metabolites |
|
|
Term
|
Definition
| GI, Rash, LFTs. hypoTG, Hypokalemia |
|
|
Term
| Itraconazole- drug interactions |
|
Definition
| Fatal arrhythmia if given with cisapride or quinidine |
|
|
Term
| Intriconazole- Liver enzyme |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Fluconazole- protein binding |
|
Definition
|
|
Term
|
Definition
Reversible alopecia
GI, Rash, LFTs |
|
|
Term
| Fluconazole- Contraindications |
|
Definition
| Pregnancy- results in fatal skeletal and cardiac muscle deformities |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| variable- dependson drug concentration, non linear kinetics |
|
|
Term
| Voriconazole- liver enzymes |
|
Definition
| Potent CYP3A4 inhibitor--> drug interactions |
|
|
Term
|
Definition
Visual changes, Cardiovascular, CNS
Rash, LFTs |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Candida, Apergillus, Zygomycetes |
|
|
Term
| Posconazole- protein binding |
|
Definition
|
|
Term
|
Definition
| hepatic metabolism --> feces |
|
|
Term
|
Definition
|
|
Term
| Posconazole- liver enzymes |
|
Definition
| CYP3A4- moderate inhibitor |
|
|
Term
|
Definition
Cardiovacular- HTN, hpokalemia
CNS- headache, dizziness
GI, LFTs |
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