Term
| To which classification of mycoses do the following belong: dermatophytes (tinea, ringworm, onychomycoses) and candidiasis (vulvovaginal, oral, esophageal)? |
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Definition
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Term
| To which classification of mycoses do the following belong: candidiasis, aspergillosis, blastomycosis, histoplasmosis, coccidiomycosis? |
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Definition
| systemic mycosis (mostly opportunistic) |
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Term
| What are 3 classes of mycoses? |
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Definition
| superficial, subcutaneous, systemic mycoses |
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Term
| Which are usually more toxic: antifungal drugs or Abx? |
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Definition
| difficult to design drugs selectively toxic to fungi but not human cells- antifungals more toxic. |
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Term
| What are 5 antifungal classifications? |
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Definition
| azoles, allylamines, polyenes, echinocandins, misc. |
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Term
| To which antifungal class do the following belong: topical: clotrimazole, miconazole. systemic: ketoconazole, fluconazole, itraconazole, voraconazole? |
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Definition
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Term
| To which antifungal class does the following belong: terbinafine (lamisil)? |
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Definition
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Term
| To which antifungal class do the following belong: amphotericin B, nystatin? |
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Definition
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Term
| To which antifungal class do the following belong: caspofungin, micafungin? |
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Definition
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Term
| To which antifungal class do the following belong: griseofulvin, flucytosine? |
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Definition
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Term
| What do the following medications tx: creams, lotions, powders, sprays. clotrimazole (lotrimin AF)- otc. miconazole (desenex)- otc. econazole (spectazole), oxiconazole (oxistat), sertaconazole (ertaczo)- rx? |
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Definition
| tx: tinea infections (foot, groin) |
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Term
| What do the following medications tx: specially formulated creams, tablets, and suppositories. otc- clotrimazole, miconazole. rx- econazole, terconazole? |
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Definition
| tx: vulvovaginal candidiasis (candida albicans) |
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Term
| What are the drug interactions of ketoconazole (nizoral)? |
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Definition
| potent inhibitor of CYP 3A4 enzyme |
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Term
| What is the most common rx azole for Candida infections? Is it rx for prevention or tx? |
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Definition
| systemic azole: fluconazole (diflucan)- for prevention and tx |
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Term
| What are the drug interactions of Fluconazole (diflucan)? |
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Definition
| potent inhibitor of CYP 2C9 |
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Term
| What are the drug interactions of Itraconazole (Sproanox)? |
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Definition
| potent inhibitor of CYP 3A4 enzyme |
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Term
| What are the ADRs of voriconazole (vfend)? |
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Definition
| adr: transient vision disturbances (30%) |
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Term
| What are the drug interactions of Voriconazole? |
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Definition
| metabolized by, and is an *inhibitor* of, cyp 2c19 |
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Term
| What are the drug interactions of phenytoin- a common convulsant? |
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Definition
| metabolized by, and is an inducer of, cyp 2c19 |
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Term
| What is an older polyene antifungal used in OTC topical creams and ointments that can sometimes be given as oral suspension for oral thrush? |
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Definition
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Term
| What is an older oral antifungal for dermatophyte infections? It involves poor tolerance due to allergic rxns, photosensitivity, gi distress and neurologic effects? |
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Definition
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Term
| How must griseofulvin be taken for best absorption? |
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Definition
| high fat meal for best absorption |
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Term
| What is an antifungal agent given in IV form for severe systemic infections w/amphotericin B that is converted to 5-fluorouracil intracellularly: very toxic? |
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Definition
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