Term
| AE: sedation, long QT, arrhythmias; drug? |
|
Definition
|
|
Term
|
Definition
| blocks uptake 1, alpha1, H1, H2, and muscarinic receptors |
|
|
Term
| do not prescribe more than 1 wk supply of __ |
|
Definition
|
|
Term
|
Definition
| imipramine, desipramine, amitriptyline |
|
|
Term
| causes the worst side effects of all the TCAs |
|
Definition
|
|
Term
| causes the least side effects of all the TCAs |
|
Definition
|
|
Term
1. TCA that preferentially blocks 5-HT receptors
2. TCA that preferentially blocks NE receptors |
|
Definition
1. imipramine
2. desipramine |
|
|
Term
| TCA drug interactions with tyramine, MAOi, monoamines, sedatives, and EtOH |
|
Definition
| decreases tyramine effect; potentiates MAOi, monoamines, sedatives, and EtOH |
|
|
Term
| phenelzine, tranylcypromine; class? |
|
Definition
|
|
Term
1. MAO-A metabolizes __
2. MAO-B metabolizes __ |
|
Definition
1. A -> 5-HT, tyramine
2. B -> NE, epi |
|
|
Term
| general effect of TCA vs. MAOi |
|
Definition
TCA = sedative
MAOi = stimulant |
|
|
Term
| AE: orthostatic hypotension |
|
Definition
|
|
Term
MAOi drug interaction with...
1. levodopa or meperidine
2. SSRI |
|
Definition
1. hypertensive crisis
2. serotonin syndrome |
|
|
Term
| potentiates tyramine effects |
|
Definition
|
|
Term
|
Definition
| fluoxetine, paroxetine, sertraline |
|
|
Term
|
Definition
| blocks 5-HT and NE reuptake |
|
|
Term
| first line treatment for MDD |
|
Definition
|
|
Term
|
Definition
| nausea, headache, sexual dysfunction, anxiety |
|
|
Term
| how long do antidepressant drugs take to see a clinical effect? |
|
Definition
|
|
Term
MOA of...
1. trazodone
2. buproprion
3. venlafaxine
4. SSRIs |
|
Definition
1. trazodone: blocks 5-HT2 receptors and reuptake
2. buproprion: blocks NE and DA reuptake
3. venlafaxine: blocks NE and 5-HT reuptake
4. SSRIs: blocks NE and 5-HT reuptake |
|
|
Term
| class and uses for trazodone |
|
Definition
|
|
Term
| why is buproprion commonly recommended for younger patients? |
|
Definition
| fewer sexual side effects |
|
|
Term
| AE: tardive dyskinesia, akathisia, hyperglycemia, extrapyramidal |
|
Definition
|
|
Term
| AE: rash, steven johnson syndrome (10%) |
|
Definition
|
|
Term
| indications for carbamazepine or valproate |
|
Definition
|
|
Term
| MOA: starves cell of inositol |
|
Definition
|
|
Term
| AE: tetralogy of Fallot if given in 1st trimester |
|
Definition
|
|
Term
| very small therapeutic index |
|
Definition
|
|
