Term
| antimetabolites, bleomycin, microtubule inhibitors, etoposide |
|
Definition
|
|
Term
| alkylating agents, antibiotics, sterod agonists/antagonists, cisplatin |
|
Definition
|
|
Term
| nausea/ vomiting, stomatitis, alopecia, myelosupression |
|
Definition
| AE chemotherapeutic drugs |
|
|
Term
| Doxorubicin, Taxol toxicity |
|
Definition
|
|
Term
|
Definition
|
|
Term
| cyclophosphamide toxicity |
|
Definition
|
|
Term
|
Definition
|
|
Term
| vincristine, cytarabine toxicity |
|
Definition
|
|
Term
| extravasation, nausea vomiting, hypersensitivity, diarrhea |
|
Definition
| acute chemotherapy toxicities |
|
|
Term
| myelosupression, alopecia, stomatitis, GI toxicity, diarrhea |
|
Definition
| delayed chemotherapy toxicities |
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|
Term
|
Definition
| compete with natural substrate for active site on enzyme or receptor, interfere/inhibit the synthesis of essential cellular elements. CCS |
|
|
Term
| Methotrexate (mexate, folex) |
|
Definition
| anticancer, antimetabolite- inhibits dihydrofolate reductase. high doses curative for esteogenic sarcoma and choriocarcinoma + lecovorin rescue. AE= BMS, NVD, stomatitis, urticaria, alopecia, crystalluria, renal/hepatic/pulmonary toxicity, learning disability in children, teratogenic |
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|
Term
| Fluorouracil (5FU, adrucil) |
|
Definition
| anticancer,antimetabolite- inhibits thymidine synthesis- cell death. AE= hand-foot syndrome |
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|
Term
|
Definition
| anticancer,antimetabolite- 5-FU, thymidine starvation, tumor specific. oral |
|
|
Term
| 6-mercaptopurine (purinethol) |
|
Definition
| anticancer, antimetabolite- purine analog, inhibition of purine synthesis= nonfxnl RNA/DNA |
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|
Term
|
Definition
| anticancer, antimetabolite- pyrimidine analog, inhibits DNA polymerase and retards chain elongation, neurotoxic |
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|
Term
|
Definition
| anticancer- antibiotic, anthracycline antiobiotic. CCS. intercalation of DNA, generation of oxygen radicals. P-glycoprotein resistance. AE cardiotoxicity |
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|
Term
|
Definition
| anticancer- antibiotic, CCS. DNA binding, oxygen radical formation and strand scission. P glycoprotein resistance. TX for testicular tumors. AE= pulmonary toxicity |
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|
Term
|
Definition
| anticancer- alkylating agent, CCNS. oral, p450 required for activation. AE= hemorrhagic systitis, secondary malignancies |
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Term
|
Definition
| anticancer, alkylating agent. AE- emesis,nephro/neuro/oto-toxicity, secondary malignancies |
|
|
Term
| Vincristine (oncovin, vcr) |
|
Definition
| anticancer, microtubule inhibitor- bind tubulin, block mitosis. CCS. P-glycoprotein resistance. AE= phlebitis, NVD, alopecia, mucositis, neurotoxic |
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|
Term
|
Definition
| anticancer, microtubule inhibitor- reversibly binds to tubulin, super rigidity. CCS, P-glycoprotein resistance. |
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|
Term
|
Definition
| anticancer, hormone- lymphocytopenic, action via nuclear transcription factors. AE= similar to glucocorticoids, ↑ appetite, cushing syndrome, puffy face, buffalo hump, cataracts |
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|
Term
|
Definition
| anticancer, hormone- SERM, binds to estrogen receptor but no effect, depletes estrogen receptors- not effective in premenopausal women. |
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|
Term
|
Definition
| anticancer, aromatase inhibitor- need hydrocortisone replacement; starve estrogen sensitive tumors |
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Term
|
Definition
| anticancer, aromatase inhibitor; starve estrogen sensitive tumors |
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Term
|
Definition
| anticancer, aromatase inhibitor- irreversible inhibitor; starve estrogen sensitive tumors |
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|
Term
|
Definition
| anticancer, hormone- gonadotropin release hormone analog, ↓ release of FSH, LH. TX prostatic cancer. |
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|
Term
|
Definition
| anticancer, monoclonal antibodies- antibody against human epidermal growth factor receptor protein 2 (HER2). inhibits proliferation of specific cancer cells. |
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Term
|
Definition
| anticancer, monoclonal antibodies- antibody against CD20--> B lymphocytes. |
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|
Term
|
Definition
| anticancer, monoclonal antibodies- Anti-VEGF (vascular endothelial growth factor)blocks growth of vascular tree |
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|
Term
|
Definition
| anticancer- blocks tumors access to asparagine. AE= hypersensitivity, hepatic dysfunction, seizures, coma, pancreatitis |
|
|
Term
| Interferon Alfa-2b (roferon-a) |
|
Definition
| anticancer- stimulates natural killer cells. TX hair cell leukemia |
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|
Term
|
Definition
| anticancer- topoisomerase I&II inhibitors, winds DNA up too tight and pops |
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Term
|
Definition
| anticancer- mTOR kinase inhibitors |
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