Class 1A

Slows conduction velocity of phase 0

↑ AP duration

↑ refractory period

(interact medium with Na channels)

Class 1A

(inhibits Na, metabolite inhibits K)

Slows conduction velocity of phase 0

↑ AP duration

↑ refractory period

(interact medium with Na channels)

CLass 1B

Slows conduction velocity of phase 0

↓ AP duration

↓ Refractory period

(Interact fast with Na channels)

Class 1C

Greatly Slows conduction velocity of phase 0

↑ AP duration

↑ refractory period

(interact slowly with Na channels)

Class 1A

Slows conduction velocity of phase 0

↑ AP duration

↑ refractory period

(interact medium with Na channels)

Slows conduction velocity of phase 0

↓ AP duration

↓ Refractory period

(Interact fast with Na channels)

Greatly Slows conduction velocity of phase 0

↑ AP duration

↑ refractory period

(interact slowly with Na channels)

↓ Conduction velocity

↓ Abnormal impulse formation

Amiodarone

Class 1

Class 2

Class 4