Term
|
Definition
| Zidovudine, Zalcitabine, Diadanosine, Stavudine, Abacavir, tenofovir, Lamivudien, emcitabine |
|
|
Term
|
Definition
| substrate for RT, lack 3'OH group can't elongate RNA |
|
|
Term
| NRTI's- what cells does it work in |
|
Definition
|
|
Term
|
Definition
|
|
Term
| What is given to mother to prevent spread of HIV during child birth |
|
Definition
|
|
Term
|
Definition
Lactic Acidosis (mtDNA interference)
hepatic steatosis
N/V/D, fatigue, insomnia
drugs with a d cause reversible, does dependent peripheral neuropath |
|
|
Term
|
Definition
|
|
Term
|
Definition
Bone marrow suppression
malaise, myopathies, N/V, HA |
|
|
Term
| Zidovudine- Contraindications |
|
Definition
| Don't give to people with Ganciclovir, used to tx CMV |
|
|
Term
|
Definition
|
|
Term
|
Definition
| peripheral neuropathy, pancreatitis |
|
|
Term
|
Definition
|
|
Term
|
Definition
Pancreatitis- deadly
Peripheral neuritis is common |
|
|
Term
|
Definition
| Do not take with meals, acid will destroy the drug |
|
|
Term
|
Definition
|
|
Term
|
Definition
lipodystrophy- prevrent with pravastatin and atrovastatin
peripheral nueropathy |
|
|
Term
|
Definition
|
|
Term
|
Definition
| hypersensitivity rxn- deadly |
|
|
Term
|
Definition
|
|
Term
| Lamivudine, emtricitabine- AE |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Nevirapine, delavirdine, enfavirenz, etravirine, rilpirivine |
|
|
Term
|
Definition
| non competitive antagonist of RT |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| 1 codon change- very common |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Nevirapine- effect on CYP450 |
|
Definition
|
|
Term
| Delvaridine- CYP450 inducer or inhibitor |
|
Definition
|
|
Term
|
Definition
| Abnormal CNS effects- vivid dreams, insomnia, dizziness |
|
|
Term
|
Definition
| don't take with fatty meals |
|
|
Term
| Efavirenz- Contraindications |
|
Definition
|
|
Term
|
Definition
| last line, NNRTI is have developed resistance to all the others |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Indinavir, atazanavir, tipranavir, fosamprenavir, lopinavir, nelfinavir, ritonavir, saquinavir |
|
|
Term
|
Definition
| binds to active site of protease --> cant cleave the polyprotein |
|
|
Term
|
Definition
|
|
Term
|
Definition
| hyperglycemia, dyslipidemia, lipodystrophy, osteoperosis, GI disturbances, redistribution of fat from face and extremities to waist |
|
|
Term
|
Definition
|
|
Term
|
Definition
redistribution of fat from face and extremities to waist, HIV lymphodystrophy syndrome.
Tx atrovastatin, provastatin |
|
|
Term
|
Definition
| inhibitors or CYP3A4 --> lots of drug interactions |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| PI- order of CYP3A4 interactions |
|
Definition
Ritonavir- greatest
squinavir- least |
|
|
Term
|
Definition
Kidney stones
hyperbillirubinemia
alopecia |
|
|
Term
|
Definition
prolonged PR- messes up atria
hyperbiirubinemia |
|
|
Term
| Tipranavir- Intracranial hemorrhage |
|
Definition
|
|
Term
|
Definition
| largest inhibitor of CYP3A4 enzyme --> inhibits metabolism of other HIV drugs, so saves $ |
|
|
Term
|
Definition
|
|
Term
|
Definition
| binds to gp41 env protein and prevents fusion of HIV to cell |
|
|
Term
|
Definition
| 1 codon change, low barrier |
|
|
Term
| Enfuviritide- HIV1,2, both |
|
Definition
|
|
Term
|
Definition
| last ditch when all other drugs have failed |
|
|
Term
|
Definition
| Injection site rxns, N/D, fatigue, Neutropenia |
|
|
Term
|
Definition
|
|
Term
| Enfuviritide- protein binding |
|
Definition
|
|
Term
|
Definition
| Proteloytic degridation, not hepatic metabolism |
|
|
Term
|
Definition
Maraviroc
Raltegavir
Etravirine |
|
|
Term
|
Definition
| binds to CCR5, CCR5 antagonists, HIV can't bind |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| really an NNRTI that is used when other drugs have failed |
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