Term
| Mycobacteria (major pathogenic species) |
|
Definition
| M. tuberculosis, M. leprae, M. avium intracellulaire |
|
|
Term
| Leprosy = Hansen's disease |
|
Definition
|
|
Term
|
Definition
|
|
Term
| inhalation of airborne droplet if nuclei (< 10 bacilli) |
|
Definition
|
|
Term
| Phagocytosis by macrophages (Tuberculosis) |
|
Definition
| multiply intracellularly if not activated; may be transported to extrapulmonary sites |
|
|
Term
| Formation of tubercle (tuberculosis) |
|
Definition
| dormant in granuloma if immune system activates; If not, liquefaction occurs (air-filled cavity) |
|
|
Term
| productive cough, fever, weight loss, hemoptysis, anorexia, fatigue, night sweats, "consumption" |
|
Definition
|
|
Term
| skeletal, GU, GI, cutaneous, lymph nodes, CNS; Congenital TB |
|
Definition
|
|
Term
| INH: nonenzymatic metabolism |
|
Definition
| associated with s0low acetylator phenotype; is hydrazide of isonictotinic acid, reversible neurotoxicity |
|
|
Term
|
Definition
|
|
Term
|
Definition
| may be more prone to hepatotoxicity |
|
|
Term
|
Definition
| excreted unchanged or as nonenzymatic hydrazine conjugates |
|
|
Term
|
Definition
| due to depletion of vitamin B6 (cofactor in all aminotransferases, always supplement with pyridoxine) |
|
|
Term
|
Definition
| semisynthetic derivatives of macrocycles first isolated for Streptomyces Mediterranei |
|
|
Term
|
Definition
| wide spectrum of activity but resistance emerges rapidly when used alone; combination with cloxacillin for serious S. aureus infections |
|
|
Term
| inhibits bacterial but not eukaryotic RNA polymerase |
|
Definition
|
|
Term
| DOC for meningitis form of TB; orange-pink coloration of ALL body fluids |
|
Definition
|
|
Term
| inhibits mycolic acid transfer into cell wall; inhibition of RNA synthesis; increase penetration of other drugs; dose-dependent optic neuropathy |
|
Definition
|
|
Term
| resistant to at least INH and Rif |
|
Definition
|
|
Term
| multi drug resistant TB + any grou in 2 + any fluoroquinolones (group 3); extremely difficult to treat |
|
Definition
|
|
