Term
| Which receptors do anti-cholinesterases work at? |
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Definition
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Term
| Which receptor is on skeletal muscle? |
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Definition
|
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Term
| Why don't most standard doses effect the nicotinic receptors on the paravertebral sympathetic chain? |
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Definition
| the dose needs to be high to get there |
|
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Term
| What sympathetic nerve has a muscarinic receptor? |
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Definition
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Term
| How many subunits does the nicotinic receptor have and how many ach are needed to activate it? |
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Definition
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Term
| How does AchE inactivate the Ach? |
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Definition
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Term
| Which synaptic cleft are the Ach receptors on? |
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Definition
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Term
| What symptom does the patient get with increased Ach at the nicotinic skeletal muscle receptors? |
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Definition
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Term
| What will inactive the Ach if it leaks outside of the synaptic cleft? |
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Definition
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Term
| Which anti-cholinesterase drugs are quickly reversible? |
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Definition
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Term
| Which anti-cholinesterase drugs are slowly reversible? |
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Definition
| Neostigmine, Pyridostigmine, Physostigmine |
|
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Term
| Which two of the slowly reversible anti-cholinesterase drugs are postively charged and therefore will not go into CNS? |
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Definition
| Neostigmine, Pyridostigmine |
|
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Term
| What are the irreversible anti-cholinesterase drugs? |
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Definition
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Term
|
Definition
|
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Term
| What 6 conditions are contraindications for use of anti-cholinesterases? |
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Definition
GI block
UT block
Hyperthyroid
Coronary Artery Disease
Peptic Ulcer Disease
Asthma |
|
|
Term
| What is Myasthenia Gravis? |
|
Definition
| an autoimmune disorder that attacks the Ach receptors |
|
|
Term
What are the symptoms of Myasthenia gravis?
Which muscles does it effect first? |
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Definition
weakness and fatigue of small muscles first
ptosis |
|
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Term
| What is the test for Myasthenia Gravis? |
|
Definition
Give Edrophonium and if Myasthenia Gravis is present they will get better because there will be an increase in Ach that can get to the few receptors that are left
in a normal patient nothing will happen |
|
|
Term
| What is the treatment for Myasthenia Gravis? |
|
Definition
| Neostigmine and Pyridostigmine because they will not cross into CNS |
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Term
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Definition
| trabecular network breaks downs causing the canals of schlemm to close and increase the intraoccular pressure |
|
|
Term
| WHat is the treatment for glaucoma? |
|
Definition
|
|
Term
| What are the results to the eye with treatment of glaucoma? |
|
Definition
miosis (constriction)
ciliary muslces contract and cause farsightedness |
|
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Term
| What is Alzheimers treated with (what is special about these drugs)? |
|
Definition
Tacrine
Aricept (Donepezil)
they are not charged |
|
|
Term
| What two drugs are used to reverse the anti-cholinesterases? |
|
Definition
|
|
Term
| What is the MOA of atropine? |
|
Definition
| protects the muscarinic Ach receptors |
|
|
Term
| What is the MOA of 2-PAM? |
|
Definition
| it restores AchE activity |
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