Term
|
Definition
| Anolog of Adriamycin (doxorubacin) and used in patients with cardiovascular risk |
|
|
Term
|
Definition
| analog of cisplatin and has less nephrotoxic effects |
|
|
Term
| cell cycle phase specific |
|
Definition
| antimetabolites and vinka alkaloids |
|
|
Term
| cell cycle phase non-specific |
|
Definition
| alkylating agents and cisplatin |
|
|
Term
|
Definition
| refractory to chemotherapy |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Procarbazine, Antimetabolites, hydroxyurea, canptothecins |
|
|
Term
|
Definition
| bleomycin, vinka alkaloids, taxanes |
|
|
Term
|
Definition
| vinka alkaloids and taxanes |
|
|
Term
| nitrogen mustards (classic alkylating |
|
Definition
| mechlorethamine, melphalan, cyclophosphamide, chlorambucil |
|
|
Term
| nitrosoureas (classic alkylating) |
|
Definition
|
|
Term
|
Definition
| carboplatin, cisplatin, oxaliplatin |
|
|
Term
| non-classic alkylating agents |
|
Definition
| procarbazine and bendamustine |
|
|
Term
|
Definition
| most favored residue for DNA alkylation leading to cross-linking |
|
|
Term
| interstrand cross-linking |
|
Definition
| guanine on 2 opposite strands |
|
|
Term
| intrastrand cross-linking |
|
Definition
| guanine on 2 different strands |
|
|
Term
| ALL Alkylating agents: SE |
|
Definition
| myelosuppression, GI toxicity and N/V |
|
|
Term
| mechlorethamine side chain |
|
Definition
| small side chain allows for most potent activity |
|
|
Term
|
Definition
| longer side chain with cyclic group that make it have moderate activity |
|
|
Term
|
Definition
| very lipophilic allowing for blood brain barrier penetration, only ones used for brain cancer |
|
|
Term
| mechloroethamine for Hodgkin's and non-Hodgkin's lymphoma |
|
Definition
| paired with vincristine, procarbazine, prednisone |
|
|
Term
|
Definition
| extravasation can occur, myelosuppression, N/V, alopecia and menstrual irregularities |
|
|
Term
|
Definition
| prodrug that must be activated through hydroxylation into haldol phosphamide |
|
|
Term
| phosphoramide mustard and acrolein (toxic) |
|
Definition
| active metabolites of cyclophosphamide |
|
|
Term
|
Definition
| bladder irritation due to acrolein toxicity; ameliorated with SH donors and large fluid intake |
|
|
