Term
|
Definition
Antihypertensive
Stimulates Adrenergic receptors in the CNS
Lowers SNS tone--decreases BP
likely stimulates inhibitory center |
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Term
| Sweat Gland SNS Postganglion Signal |
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Definition
|
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Term
| What stimulates dilation of skeletal muscle vasculature? |
|
Definition
| Beta 2 receptors from circulating epinephrine |
|
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Term
| Pathway from Tyrosine to Epinephrine |
|
Definition
| Tyrosine-->DOPA-->Dopamine-->NE-->Epinephrine |
|
|
Term
| What is the RLS of EPI synthesis from Tyrosine? |
|
Definition
| Tyrosine-->DOPA via dopamine hydroxylase |
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Term
|
Definition
Competitive inhibitor of tyrosine hydroxylase
Treats pheochromacytoma (catecholamine producing tumor of the adrenal medulla) |
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Term
|
Definition
Enzyme catalyzing conversion of DOPA to Dopamine
Aromatic AA decarboxylase enzyme |
|
|
Term
| Dopamine-Beta-Hydroxylase |
|
Definition
| Enzyme for Dopamine to Norepinephrine conversion |
|
|
Term
| Phenylethanolamine-N-methyltransferase |
|
Definition
Converts NE to EPI
In Adrenal Medulla |
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Term
|
Definition
| A compound that enters presynaptic storage vesicles and replaces the normal neurotransmitter. |
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|
Term
| 2 druges which interferewith storage and release of norepinephrine release from nerve terminals |
|
Definition
| Guanethidine and Reserpine |
|
|
Term
| Guanethidine's effect on BP |
|
Definition
Initially short term increase (Not seen clinically, however, because it only occurs via IV bolus, and that's not done with Guanethidine)
Then long term decrease |
|
|
Term
| Guanethidine Side Effects: (5) |
|
Definition
Orthostatic Hypotension
Excessive GI stim (unopposed PSNS)
Inhibition of Ejaculation
Pheochromocytoma especially sensitive
No CNS effect (can't cross BBB because too polar) |
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Term
|
Definition
Decreases Blood Pressure via inhibition of ATP dependent NE/Dopamine uptake carrier in vesicles
NE can't get into the vesicles--not displaced, it just runs out |
|
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Term
| Is Reserpine Lipid or Water soluble? Side effects? (4) |
|
Definition
Lipid soluble--enters CNS:
Sedation
Lethargy
Nightmares
Depression |
|
|
Term
| How does cocaine function to stop adrenergic nerve terminals? |
|
Definition
| It blocks reuptake of NE into presynaptic terminal. |
|
|
Term
| How do Tricyclic Antidepressants (TCAs) work? |
|
Definition
| It blocks reuptake of NE into presynaptic terminal. |
|
|
Term
| What is the primary mechanism of termination of the adrenergic signal? |
|
Definition
| Reuptake of catecholamines by the presynaptic nerve terminal. |
|
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Term
|
Definition
Enzyme that metabolizes catecholamines after uptake.
Mitochondrial enzyme that is widely distributed in body tissues. |
|
|
Term
| COMT Catechol-O-methyltransferase |
|
Definition
| Widely distributed Cytoplasmic enzyme. High concentrations in kidney and liver. |
|
|
Term
| Dopamine's metabolite in urine |
|
Definition
|
|
Term
| Epi and NE urinary metabolites |
|
Definition
3-methoxy-4-hydroxyphenylglycol (MHPG) and
3-methoxy-4-hydroxy-mandelic acid (VMA) |
|
|
Term
|
Definition
From use of MAO inhibitors
from foods high in tyramine
tyramine is normally broken down by MAO, but with the inhibitor present, it can't be broken, down, so the tyramine acts as a sympathomimetic. 15-20 documented deaths. |
|
|
Term
|
Definition
EPI>NE>>ISO
Vasoconstriction
Contraction of Uterus
Contraction of Nictitating Membrane
Pupillary Dilation
GI Inhibition |
|
|
Term
| Beta Receptors--order of epinephrine, NE, and ISO strengths |
|
Definition
|
|
Term
|
Definition
Cardiac Stimulation
Renin Secretion by JG cells. NE, EPI and ISO all utilized. |
|
|
Term
|
Definition
Vascular Dilation
Bronchiolar Relaxation
Iso and Epi: NO NE! |
|
|
Term
|
Definition
| Parent compound from which sympathomimetic drugs are derived |
|
|
Term
|
Definition
| Direct alpha sympathomimetic |
|
|
Term
|
Definition
| Direct alpha sympathomimetic |
|
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Term
|
Definition
| Direct alpha sympathomimetic |
|
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Term
|
Definition
|
|
Term
|
Definition
| Beta 2 agonist (bronchodilator) |
|
|
Term
|
Definition
| Beta 2 agonist (bronchodilator) |
|
|
Term
|
Definition
| Beta 2 agonist (bronchodilator) |
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