Term
| Normocytic, normochromic anemia; neutropenia, thrombocytopenia, pancytopenia |
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Definition
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Term
| chloramphenicol, carbamazepine, Felbamate, Phenytoin, Quinine |
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Definition
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Term
| microcytic, hypochromic, decreased MCV |
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Definition
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Term
| increased TIBC and decreased transferrin saturation |
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Definition
| iron studies in iron deficiency anemia |
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Term
| macrocytic anemia, increased MCV, mild leukopenia and thrombocytopenia; smear looks just like FA deficiency |
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Definition
| Pernicious/B-12 deficiency anemia |
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Term
| macrocytic, S/S similar to iron deficiency anemia |
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Definition
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Term
| phenytoin, methotrexate, colchicine |
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Definition
| Folate Deficiency Anemia causes |
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Term
| Reticulocytosis, reduced Hgb/Hct, normo or macrocytic, schistocytes/spherocytes/bite cells, increased unconjugated bilirubin, increased lactate dehydrogenase, hemoglobinuria, possibly + Coombs Test (DAT) |
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Definition
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Term
| key enzyme in production of glutathione |
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Definition
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Term
| protects hemoglobin against oxygen damage |
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Definition
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Term
| Nalidixic acid, nitrofurantoin, phenazopyridine, primaquine, sulfacetaminide, sulfamethoxazole, trinitrotoluene, volatile alkyl nitrites |
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Definition
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Term
| exceedingly rare, 3 MOA, often requires transfusions, can be fatal |
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Definition
| drug-induced immune hemolytic anemia |
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Term
| infections, cancer, autoimmune disorders (RA, SLE, inflammatory Bowel Disease), CKD |
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Definition
| Anemia of Chronic Disease Underlying Causes |
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Term
| Second most common form of anemia |
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Definition
| Anemia of Chronic Disease |
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Term
| collection of autosomal recessive genetic disorders that are characterized by the presence of at least one SS gen |
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Definition
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Term
| Sickle Cell Syndrome: Heterozygous carriers are protected from succumbing to: |
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Definition
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Term
| vaso-occlusive pain crisis; infection; CVA; acute chest syndrome |
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Definition
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Term
| Avoid taking antacids, calcium, H-2 antagonists, and PPIs with this |
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Definition
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Term
| Fluoroquinolones, tetracycline, phenytoin |
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Definition
| Iron blocks absorption of other drugs |
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|
Term
| CDC recommends iron supplementation for treatment of iron deficiency anemia |
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Definition
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Term
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Definition
| sulfate, gluconate, fumarate, polysaccharide |
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Term
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Definition
| Dextran, Sucros, Ferric Gluconate |
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|
Term
| Test dose needed, IM "Z-track" |
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Definition
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Term
| only FDA approved for use with EPO in patients with CKD; effective in IDA, costly, lower risk of anaphylaxis |
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Definition
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|
Term
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Definition
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Term
| most common, more reliable, may circumvent the need for a Schilling Test |
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Definition
| Parenteral B-12 (cyanocobalamin) |
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Term
| Hgb will increase 2 weeks after initiation of therapy and may normalize after 2-4 months |
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Definition
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|
Term
| Regulates Red Blood Cell Production |
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Definition
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|
Term
| erythropoietin stimulate the proliferation and differentiation of erythroid progenitors |
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Definition
| into reticulocytes and prevents apoptosis |
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|
Term
|
Definition
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|
Term
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Definition
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Term
| shortened survival, increased risk of tumor progression or recurrence; use if rx of anemia due to concomitant myelosuppressive chemo (do not use if cure is expected), D/C following chemo |
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Definition
| Erythropoetitic Stimulating Proteins (ESPs)-- Patients with cancer |
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Term
| decreased frequency of hospitalization and the incidence of pain, acute chest syndrome, and blood transfusions by almost 50% of patients with sickle cell disease |
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Definition
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Term
| myelosuppression, acute leukemia, chronic opportunistic infections |
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Definition
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|
Term
| secondary: smokers, chronic hypoxia, EPO, altitude |
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Definition
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Term
| folate or B-12 deficiency, chronic liver disease, chronic alcoholism, cytotoxic medications |
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Definition
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|
Term
| iron deficiency, alpha or beta thalassemia (minor), chronic disease (usually normocytic) |
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Definition
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Term
| B-12 deficient, folic acid deficient, alcoholism, some cyto-toxic drugs |
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Definition
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|
Term
| iron deficient, anemia of chronic disease, alpha or beta thalassemia, decreased MCV, if also hypochromic <--> almost certainly Fe deficient |
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Definition
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|
Term
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Definition
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Term
| helmet cell, burr cell, acanthocyte, seen in fragmentation syndromes such as mechanical valvular and hemolytic anemias |
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Definition
| Schistocyte- deformed or broken RBC |
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Term
| crescent shaped RBCs pointed at one or both ends; found in some patients with homozygous sickle cell anemia |
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Definition
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|
Term
| iron delivery and transport |
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Definition
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|
Term
| measures the blood's capacity to bind iron with transferrin (indirect measure of transferrin) |
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Definition
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|
Term
| determines the ability to absorb B-12 from the GI tract |
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Definition
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